From Screening to Confirmation: Integrated POPs Analysis Workflow

Manage webcast
Dirk Krumwiede, Hans-Joachim Huebschmann
This webinar focuses on the workflow for the analysis of Persistent Organic Pollutants (POPs) with the determination of dioxin/furans in food samples. A new concept for the combined and integrated use of screening and confirmation methods will be presented. The application of dedicated highly selective mass spectrometry technologies for the analysis of dioxins and furans in milk samples will be discussed using real-life data.

What you will learn:

- What is POPs screening? What is confirmation? How do the analytical requirements differ for these tasks?
- Sample analysis workflow from fast screening to precise confirmation analysis.
- Latest GC-MS/MS triple quadrupole mass spectrometry solution for optimum screening analysis.
- Latest GC-HRMS magnetic sector mass spectrometry solution for optimum confirmation analysis.
- Integrated data evaluation with a common software suite.
- Approaches and investigations for an optimized sample preparation process.
- Overall advantages of the integrated POPs analysis workflow.

Who should attend:
- Lab managers and Quality Assurance managers from food industry, contract and governmental laboratories.
- Anybody interested in effective Dioxin/Furan analysis in food, feed environmental or biological samples.
Oct 6 2010
84 mins
From Screening to Confirmation: Integrated POPs Analysis Workflow
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  • Tune in for the industry’s only inside look at how the first half of the new year shaped up. In this complimentary web event, Dianne Crocker will share the latest stats from EDR’s ScoreKeeper service on how the property due diligence market looks at mid-year—as well as what your forecast for the second half will look like. Attendees of this 60-minute webinar will learn:

    • The strength of commercial real estate investment and lending activity
    • ScoreKeeper’s barometers of regional, state and metro hot spots for Phase I ESA volume
    • Key forces driving demand for due diligence this year
    • Changes in risk tolerance from the user community
    • EDR Insight’s near-term forecast for environmental due diligence
  • Following decades of studies, scrutiny and debate, the U.S. EPA updated its TCE’s toxicity profile in the IRIS database, dramatically lowering the toxicity value. For transactional due diligence, this more stringent limit has important implications, including markedly more extensive and expensive cleanup processes. Given the focus on vapor migration in the new ASTM Phase I ESA standard, environmental professionals need to be increasingly cautious when making REC determinations and recommendations to clients.

    Adding to the confusion is the significant variability in how regulators are using the updated TCE toxicity profile when making closure decisions at contaminated properties. For instance, U.S. EPA Regions 9, 10 and states like Minnesota, Indiana and Massachusetts (among others) have implemented profoundly different approaches to address TCE risk at contaminated sites. Thus, it is critical for environmental professionals to stay abreast of the how TCE guidance is being interpreted and applied across the country. In the latest development, the Agency for Toxic Substances & Disease Registry is proposing a dramatic change to its TCE toxicity profile for the first time in 18 years. The comment period ended on March 16, 2015, and if the update is finalized in its current form, there will be more intense scrutiny on exposure risks which will further complicate transactional due diligence.

    This timely webinar will bring together an attorney and a national subject matter expert to address the various impacts of TCE’s toxicity update on transactional due diligence. This panel will help EPs answer the following questions:

    -Does TCE in groundwater constitute a VEC and/or a REC?
    -How should an EP manage variability in TCE standards in multi-state transactions?
    -How can an EP take steps to minimize exposure to potential liability?
    -How can an EP make sense of the science and available guidance?
    -How should an EP communicate potential risks associated with TCE to clients?
  • Commercial real estate markets continue their slow recovery. As demand for loans intensifies, regulatory compliance is top of mind for financial institutions. Bank regulators are exercising strict oversight over all types of bank underwriting, including commercial appraisals. This webinar will address head-on the challenges that institutions face in meeting the latest guidance impacting the appraisal function, and what risk managers can and should be doing to survive an appraisal compliance audit.

    Attendees will receive answers to these important questions:

    • What do current guidance/regulations require of banks related to appraisals and how has that changed?
    • What specific things are bank examiners looking for in an appraisal compliance audit?
    • Are you doing everything you can to prepare your institution for the scrutiny of examiners before an audit? During an audit? After an audit?
    • What are the latest best practices that banks should include today in their appraisal policies to protect themselves during this stage of market recovery?

    EDR Insight is fortunate to have Mitch Kreeger for this timely event. Kreeger is a well-known Subject Matter Expert (SME) on various valuation, environmental and seismic risk, and regulatory compliance topics by peers nationwide. Currently, Kreeger is Chief Appraiser and Principal Consultant at Kreeger Consulting, a private appraisal/environmental/seismic risk consulting services firm that offers commercial appraisal reviews, outsourced Chief Appraiser duties, and advisory services to lenders on regulatory compliance, efficient appraisal/environmental risk functions, and effective policy updates.

    • Primary: Risk managers at financial institutions, particularly at community bank level
    • Secondary: Commercial appraisers
  • Exposure to professional liability ranks high on the list of any environmental professional’s concerns. In this webinar, industry veteran Anthony Buonicore will present five carefully-selected case studies where an EP was sued, highlighting how costly litigation could have been avoided. Attendees of this webinar will come away with steps that can be taken to minimize professional liability exposure when:

    • Submitting a Phase I ESA proposal
    • Conducting a Phase I ESA
    • Writing the Phase I ESA report
  • With risk management in the spotlight, environmental risk management policies are more important than ever. Environmental insurance options have evolved to offer lenders proven ways to manage risk as commercial loan originations increase in the second act of market recovery. Join us for this webinar as seasoned insiders share their insight into how insurance policies can effectively manage risk exposure. Attendees will also learn how environmental insurance can be applied to lending practices based on real world examples of claims scenarios.

    Benefits to attendees:
    • Background on the latest tools available to help lenders protect collateral on real estate loans or investments.
    • The know-how to avoid an embarrassing loss on loan portfolios due to environmental issues.
    • The latest intel on how lender environmental insurance can help lenders make more loans.

    Target audience:
    • Risk managers at community banks
    • Risk managers at national/international banks looking for a refresher
    • Credit managers and chief credit officers
    • Environmental due diligence professionals serving lenders
    • Insurance professionals
  • Vapor migration is part of the new Phase I environmental site assessment protocol from ASTM, E 1527-13. In December, the US Environmental Protection Agency blessed the new standard as compliant with the federal All Appropriate Inquiries rule, emphasizing the importance of assessing vapor migration risk as a standard part of Phase I ESAs. US EPA went even further in the December preamble and stated that vapor migration has always been a part of conducting AAI. In light of US EPA’s statements and the emphasis that assessing vapor migration is current standard practice for AAI-compliant Phase I ESAs, how is vapor being addressed in the field? If a Phase I ESA report identifies vapor migration as a Recognized Environmental Condition, or REC, what next? In today’s market of intensely short turnaround times for property transactions, is a vapor migration issue a deal killer? What are the current tools and options to investigate a vapor migration REC under transactional time constraints? When should a buyer walk away from a site potentially impacted by vapor migration? When to mitigate? How are environmental due diligence firms establishing consistent processes for recommending “next steps” for clients when vapor migration issues arise?

    This timely webinar will bring together an attorney and two leading technical experts to address head-on the various avenues that firms are taking to assist end users of Phase I ESA reports on how to address vapor migration risk during the deal making process.
  • Regulatory pressures are fundamentally impacting the way that financial institutions manage the appraisal function. Our speakers will tackle the most impactful issues for both lenders and appraisals today. An expert from the Appraisal Institute, the largest appraisal membership society in the world with 23,000+ real estate valuation experts worldwide, will share first-hand research into the challenges faced by appraisers and by lenders that rely on the technical expertise of appraisal services. Attendees will learn about the concerns commercial real estate appraisers face, and the challenges their lender clients face in finding quality appraisers to help them respond to new policies and requirements. Speakers will also share insight into the latest policies from bank regulators like the OCC and FDIC that are impacting the integration of appraisals and environmental risk management. An expert in the trenches of a small community bank will share his insights into the shifting alignment of appraisals and environmental risk management at the community bank level, the importance of having a sound policy in place and actions that banks can take to best prepare for the scrutiny of examiners.

    - Information on how appraisers can meet today’s top challenges, align their services with the challenges lender clients face
    - A deeper understanding of bank regulations impacting appraisals
    - An insider’s take on what bank examiners look for
    - Advice on steps banks can take to protect themselves against examiner scrutiny
    - A look into the forces that are bringing appraisals and environmental due diligence functions closer together

    - Bill Garber, Director of Government and External Relations, Appraisal Institute
    - Brian Ginter, Director - Executive Staff, Diversified Real Estate Consulting Network
  • With scrutiny on lenders’ risk management policies intensifying, more and more community banks are writing their first policies or updating old ones. The OCC just raised the bar for the banks it regulates with the August release of expanded guidelines for environmental risk management that bring their policy requirements in line with those of the FDIC. What are the critical components that should be in every policy? What elements are common to most institution’s policies? How does your institution measure up to industry best practices? How is policy administered across organizations?

    Join us for this webinar as seasoned insiders selected from the ranks of a mid-sized bank and small community lender share their experiences in writing and updating environmental policies. Learn what these experts are doing to protect their institutions from environmental risk exposure, and the dangers that lenders face by not having adequate policies in place to protect them from financial and legal liability.
  • Do you have more questions than answers about the industry’s transition over to a new ASTM Phase I ESA protocol? You’re not alone.

    On August 15, 2013, the U.S. Environmental Protection Agency published a Direct Final Rule which proposes to reference the E 1527-13 standard as compliant with the agency’s All Appropriate Inquiries rule (40 CFR Part 312). The agency’s 30-day public comment period just closed and the ASTM standard moves one step closer to publication.

    Right now the #1 question in the industry is: When will ASTM E 1527-13 take effect?

    At this webinar, two of the experts closest to the ASTM process will share the latest status of the AAI rule amendment and publication of the new Phase I ESA standard.

    There are a number of moving pieces in play right now. Tune into this event to learn the latest on the ASTM front, the hot-button issues raised during the public comment period, what happens to E 1527-05 and more. It is an important time for the industry as it prepares to put a new standard into effect and this event will help keep environmental professionals abreast of the process as it unfolds.


    Julie Kilgore, President, Wasatch Environmental, Inc., Chair of ASTM E50 Committee on Environmental Assessment, Risk Management and Corrective Action and Chair of the E1527 Task Group

    William Weissman, attorney, member of ASTM E50 Executive Subcommittee, retired partner of Venable LLP, Washington, DC
  • Change is in the air on the vapor intrusion front. Literally and figuratively. On April 16, the U.S. Environmental Protection Agency released a draft document, the OSWER Final Guidance For Assessing And Mitigating The Vapor Intrusion Pathway From Subsurface Sources To Indoor Air — External Review Draft for public comment. The release of EPA’s guidance comes just months before ASTM is poised to release a revised version of E 1527 that adds definitions of migrate/migration to address the vapor pathway as a potential conduit for contamination.

    As attention being placed on vapor risk increases, environmental professionals need to stay abreast of the changes and their implications. With the long-awaited federal guidance now out for public comment, environmental due diligence professionals, lenders, as well as prospective purchasers of properties like drycleaners, gas stations, and other types of properties impacted by petroleum or solvents have a valuable resource for understanding VI risk, assessing it and ultimately, managing it as appropriate for their own risk tolerance. Join us at this webinar to hear the perspectives of three experts on:

    • The implications of the federal vapor guidance and an insiders’ unique take on hot button issues;
    • How one environmental professional talks to his clients about vapor risk and protects their liability exposure; and
    • How vapor risk is being mitigated and managed in today’s deals.
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  • Capsules for Use in Dry Powder Inhalers (DPIs) in Early Phase Dev Recorded: Jun 28 2011 69 mins
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    Finding efficient drug delivery methods is becoming increasingly important as the pharmaceutical industry looks to improve the performance of its new compounds and extend the applications of existing drugs. One option that has long been used to successfully treat respiratory conditions and provide compounds with a fast-acting route into circulation is drug delivery via inhalation using a dry powder inhaler (DPI).

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    Matt Richardson, Pharmaceutical Business Development Manager, Capsugel
    Matt has a BS in Chemistry (Wofford College) and Ph.D. (Wake Forest) in synthetic organic and organometallic chemistry. Prior to joining Capsugel in 2005, he worked in process development and scale up of pharmaceuticals.

    Massimo Moratto, Senior Scientist Pharmaceutical Development, Aptuit
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  • From Screening to Confirmation: Integrated POPs Analysis Workflow Recorded: Oct 6 2010 84 mins
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  • Dewpoint Moisture Content: A New Method Moisture Content Analysis Recorded: Jun 8 2010 69 mins
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    1) The Dewpoint Moisture Content method will be introduced

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  • What’s in your vial? Best practices for microbial QC strains Recorded: Apr 28 2010 84 mins
    Elizabeth Kerrigan, Jaspreet Sidhu, Ph.D.
    What’s in your vial? Best practices for maintaining microbial QC strains.

    Elizabeth Kerrigan
    Director, Standards and Certification,
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    Jaspreet Sidhu, Ph.D.
    Vice President of Business Development and Pharmaceutical Microbiology
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    Seminar Overview:
    In the pharmaceutical and personal care industries, products, processes and environments are quality control tested to prevent microbial contamination. Microbial strains with confirmed identity, viability and purity, produced by meticulous laboratory procedures that minimize subculturing, are important components of quality control testing programs. Responding to industry demands for rapid microbiological testing, instrumentation and associated databases have been developed that allow for the standardized testing of phenotypic and genotypic traits across a wide array of microorganisms. A polyphasic approach to identification provides strain confirmation and avoids the pitfalls of misidentification, painful recalls and regulatory repercussions. Case studies will be provided to illustrate key points.

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  • Incorporating Water Activity Testing in New Pharma Initiatives Recorded: Apr 8 2010 81 mins
    Brady Carter, Research Scientist – Decagon Devices Inc.
    Incorporating Water Activity Testing in New Pharmaceutical Initiatives

    This seminar will provide an overview of effective utilization of water activity as part of new pharmaceutical initiatives such as ICH and QBD. USP 1112 outlines strategies based on water activity that can reduce the amount of microbial limit testing needed for products with lower water activities. These strategies can be applied to drug release quality programs that are developed using ICH or QBD guidelines. The primary goal of these initiatives is to create risk-based, science backed quality programs. In terms of microbial safety of drug products, the new quality initiatives indicate that products that are “dry” are candidates for reduced microbial limits testing. Water activity is the only effective screen for “dry” conditions that prevent microbial spoilage as evidenced in scientific literature while moisture content is not. Water activity is also related to other critical quality attributes such as dissolution, excipient performance, and degradation of API. Utilization of water activity testing requires an understanding of water activity and this seminar will define water activity and describe methods for accurately measuring it. The seminar also will discuss the relationship between water activity and critical quality attributes and discuss strategies for implementing water activity testing in drug quality programs.

    5 Major Learning Objectives:

    1) What is water activity?
    2)How are water activity and moisture content different?
    3)How is water activity measured?
    4)What critical quality attributes is water activity related to?
    5)How can water activity be used with ICH?
    6)How can water activity be used with QBD?
  • Reducing Bottlenecks In GxP Laboratories Recorded: Jan 19 2010 64 mins
    Chris Stumpf, Ph.D.
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    • Electronic SOP document and workflow systems improve SOP completion times, reduce procedural and transcription errors, and reduce review & sign-off times

    • A more efficient SOP documentation process translates into a more efficient documentation workflow, more accurate records, and faster product release.

    • An electronic SOP documentation system offers the opportunity to address the three major tenets of Lean Process manufacturing: eliminate waste, improve workflows, and improve quality.


    Chris Stumpf, Ph.D.
    Senior Product Marketing Manager, Informatics
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    Chris joined Waters in 2001 after earning his Ph.D. in Analytical Chemistry and Mass Spectrometry from Purdue University in 2000, and held a post doctoral position at the University of Cincinnati Medical School conducting proteomics research. During his doctorate and post-doctorate education, he became keenly interested in informatics solutions to manage and mine analytical data
  • A Complete Moisture Analysis Recorded: Jan 13 2010 85 mins
    Brady Carter
    This seminar will highlight the importance of a complete moisture analysis consisting of both water activity and moisture content. Definitions for water activity and moisture content will be established with a particular focus on their differences. Methods for measuring water activity and moisture content as well as techniques for obtaining accurate measurements will be highlighted. The relationship between water activity and moisture content, referred to as a moisture sorption isotherm, will be described. Practical applications for water activity, moisture content, and moisture sorption isotherms will be detailed. These applications will cover both product safety and quality including: microbial safety, shelf life, ingredient mixing, temperature abuse, product formulation, caking and clumping, and package performance.

    5 Major Learning Objectives:

    1) What is water activity and moisture content?

    2) How are water activity and moisture content different?

    3) How are water activity and moisture content measured?

    4) What is a moisture sorption isotherm?

    5) How do water activity and moisture content influence product safety and quality?

    6) How can the relationships between moisture content and water activity be used to improve product formulation?
  • The Science of Food Profiling Recorded: Nov 10 2009 55 mins
    Dr. Tim Jenkins
    The Science of Food Profiling: Determining the Adulteration, Authenticity and Origin of Foods

    With reports of 5 to 10% of global food trade involving counterfeit goods, regulatory agencies and food manufacturers are compelled to employ programs that help ensure consumer safety, protect trade markets, maintain product quality and preserve brand image.

    This webinar will demonstrate how the latest analytical instrumentation and data analysis software can assist food testing laboratories in the determination of food adulteration, authenticity and origin.

    • Liquid chromatography and mass spectrometry are key analytical technologies for food profiling. The application and advantages of these techniques will be discussed.

    • Employing chemometrics software for automated data analyses can yield critical information for food testing laboratories. The approach facilitates the identification of differences or similarities between brands or manufacturing batches. This methodology will be examined.

    • Examples of edible oil, tea and fruit juice food profiling applications will be shown.


    Dr. Tim Jenkins is part of Waters Chemical Analysis Market Development group where he leads the Business Operations team. This group has particular expertise in food testing and environmental applications and addresses global market development issues. Prior to joining Waters Dr. Jenkins gained over 15 years experience of practical mass spectrometry and technical management in a variety of environments including academia, corporate R&D and contract analysis laboratories.
  • Innovative 3rd Generation Coating: BASF’s Kollicoat Recorded: Nov 2 2009 56 mins
    Vaishali Tawde and Eric Liu
    Innovative key features of the new patented PEG-PVA graft polymers are the low viscosity of the polymer solution, outstanding flexibility of the film and extremely rapid dissolution of coating. In terms of viscosity alone this new technology offers significant advantages over cellulose derivatives. Sprayable dispersions at high solids concentrations which are not sticky and fast drying ensures gains in productivity and process costs. You will gain an in-depth knowledge about these new PEG-PVA graft polymers as coatings and the proper formulation and the best process parameters for excellent performance in finished solid dosage forms. Ms. Vaishali Tawde, Technical Services Manager, South Asia, BASF India Dr. Eric Liu, Senior Technical Marketing Manager, BASF China
  • Food Safety Certification: Get the Abridged Version Recorded: Oct 8 2009 87 mins
    Catherine Francois, Kathleen Wybourn and Robert Haydu
    How do I get started with Food Safety Certification? What's the process?
    What are the GFSI benchmarked standards and which is best for my organization?

    Do these questions sound familiar? Do you have even more? Attend this information-packed webinar to get the answers to your questions and valuable details you need about Food Safety Certification.

    Catherine Francois, Consumer Goods Forum (CIES/CFSI)

    Kathleen Wybourn, DNV

    Case Study Speaker: Robert Haydu, Wm. Wrigley Jr. Company

    Attendees to the webinar that are interested in pursuing certification and using the IFS standard, will receive a free copy of the standard (a $57 value) and one free license to “auditXpress”, the IFS internal auditor software (a $290 value). To obtain these items, you must attend the webinar! (Restrictions apply, limited quantities available)
  • Hot Melt Extrusion for Poorly Soluble Drugs Recorded: Oct 6 2009 77 mins
    Scott T. Martin, Thermo Fisher, Karl Kolter, BASF
    Hot Melt Extrusion (HME) is becoming an important technology within the Pharmaceutical Industry as a means for formulating poorly water-soluble active pharmaceutical ingredients (API’s). Additionally, HME provides greater drug bioavailability. This Webinar will cover:

    • A review of Hot Melt Extrusion Technology.
    • Modification to the traditional extrusion system for pharmaceutical needs.
    • An economically-feasible continuous process and solvent-free manufacture.
    • The role of polymers and plasticizers.
    • The use of low temperatures to minimize API degradation.
    • Optimization of HME Formulation and Process.

    Scott T. Martin, Senior Application Specialist, Thermo Fisher Scientific

    Dr. Karl Kolter, Ph.D., Head of Global R&D Project Management Excipients
    BASF SE, Germany, Pharma Ingredients and Services

    BASF reserves the right to limit access to this event.
Trends and Developments
This channel will provide webinars that focus on the unique niche of post-discovery development and validation as well as webinars that examine current products, technologies. and philosophies used in laboratories; tracks the deployment of tools that processors and the food service industry professionals use to ensure safe and consistent products.

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  • Title: From Screening to Confirmation: Integrated POPs Analysis Workflow
  • Live at: Oct 6 2010 3:00 pm
  • Presented by: Dirk Krumwiede, Hans-Joachim Huebschmann
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