Doping control analysis predominantly utilises chromatography and mass spectrometry-based approaches to detect prohibited substances and methods of doping. These compounds and methods present both low and high molecular weight analytes of xenobiotic or natural / endogenous origin, which are to be detected, and occasionally quantified, using state-of-the-art instruments.
The majority of the employed tools provides low resolving power. However, high resolution / high accuracy mass spectrometry has gained much attention recently due to: constantly increasing analytical requirements concerning the number of target compounds; the complexity of analytes (e.g. peptides and proteins); and the desire to accelerate analyses and obtain information (allowing for retrospective data mining).
A selection of compounds, new challenges, and methods currently employed in doping control laboratories will be presented to the audience including, for example: new anabolic agents referred to as selective androgen receptor modulators (SARMs); insulins; so-called "releasing peptides" that stimulate the endogenous production of natural hormones; and ways of manipulating drug tests.
Sample preparation is the most important, yet often most neglected area of chromatographic training and method development. The world's finest gas and liquid chromatographs generally cannot overcome mistakes made prior to sample injection.
This webinar will focus on general principles of sampling and sample preparation for chromatography and an overview of key concepts for several major sample preparation techniques, including:
* Liquid-liquid and liquid-solid extractions (LLE and LSE)
* Static headspace extraction (SHE)
* Solid phase extraction (SPE)
* Sorptive micro-extractions (SPME and SBSE).
Discussion will directed toward seeing the commonalities among all extraction techniques and toward choosing the best technique for a given analytical problem. Fundamentals of sample and glassware handling will also be reviewed.
This webinar is directed toward analysts who use these techniques hands-on every day and to the laboratory managers who must teach, train and supervise them.
In this webinar, Professor Peter Schoenmakers will provide insight into the various LC techniques, including:
* An overall perspective of current usage and applications of the various techniques.
* A description of how the techniques developed, starting from paper chromatography up-to current "high tech" two-dimensional separations.
* A more detailed focus on the concept of various methods.
Often portrayed more as magic than science, popular television series such as CSI have aroused great interest in analytical chemistry. Forensic science relies on separation science.
Peter Schoenmakers' webinar will also, in a light-hearted manner, put LC methods into the correct perspective for forensic science.
The first activity in the Year of Education is a series of free educational webinars, run in conjunction by separationsNOW and Chromedia. In the first webinar, Professor Harold McNair gives an interactive lecture on the basics of gas chromatography.
This first webinar is intended for persons who:
* Use chromatography and would like to revisit the basics of GC.
* Have a little knowledge and would like to learn more!
Some knowledge of general and organic chemistry is assumed. The webinar should prove useful to technicians, students, graduate students, PhDs and even professors planning to work with GC.
Topics to be discussed are:
* Definitions of GC
* Separation principles
* Advantages and limitations of GC
* Basic instrumental components of a GC
* Capillary columns
* Three detectors: FID,TCD and ECD
brought to you by separationsNOW.com (Wiley-Blackwell) and Chromedia
The Year of Education came about through discussions between 3 professors who actively teach chromatography:
* Professor Harold McNair, Virginia Tech, Blacksburg, USA
* Professor Pat Sandra, University of Ghent, Belgium
* Professor Peter Schoenmakers, University of Amsterdam, Netherlands
"The first activity is a free webinar on gas chromatography, followed by a number of other activities, more webinars, online short courses, tutorials, instruction videos and much more! 2010 will be a year full of activities.
Many experts will be involved, from university and industry. We believe all chromatographers should actively take part in this: in teaching, telling their employees and students to take courses. This is a chance they should not miss!"
The ImageStream® and FlowSight® are multispectral imaging flow cytometers that generates high resolution images of cells at a rate of 1000’s of cells per second. This allows for the rapid acquisition of tens of thousands of images per sample. Using the IDEAS® image analysis software, the system calculates features based not only on fluorescence intensity but the morphology of that fluorescence as well. This novel approach is able to seamlessly combine the quantitative power of flow cytometry with the high content information associated with microscopy. The system can collect data on a wide range of applications including nuclear localization during a signal transduction cascade, measuring colocalization of two probes, or quantify features on the phagocytosed particles in macrophages.
Video content accounted for 64% of all the world’s internet traffic in 2014 and is expected to grow to 80% by 2019. As the way in which we connect and digest information evolves, high quality mobile video capture and advanced digital analysis offers ever more authentic, intimate and rich insights into the customers’ world. This webinar will focus on:
– How emerging technology can enable us to realise the true value of ‘video data’ in our analysis and beyond
– How mobile technology can be used to get you closer to your customers and their real world experiences right from the earliest stages in product development
– How real world video content can engage your key stakeholders and ensure customer insights drive action
Diabetes is one of the most prevalent and most costly conditions worldwide – with a prevalence equating to 8.5% of the global population. Due to the complex nature of diabetes, with numerous co-morbidities and its asymptomatic nature, accurately modelling and therefore discerning which interventions are most effective, in terms of cost and patient impact is an equally complicated process.
This webinar will explore the patient pathway and how effective modelling – when pharma works together with healthcare stakeholders – can improve outcomes for both patients and the healthcare system as a whole.
Predictive assays are a key element of personalized healthcare because these assays aid physicians in selecting individuals who are most likely or least likely to benefit from specific therapies. In addition to analytical validation, predictive assays require clinical validation to establish their clinical utility. Krista Acosta, Manager, CDx Pharma Services Assay Development, Nicole Schechter, PSM, PMP, CDx Director, Project Leader and Alton Yates PhD, Senior Manager, Clinical Sciences Management, will address the development and performance differences between predictive assays developed under in vitro diagnostic regulations and laboratory developed tests.
Join us for a one-hour live debate on Cancer Treatment Access: Right Strategy, Right Approach, Right Outcomes.
To ensure funding and patient access to innovative cancer therapies, industry now have to navigate a new English cancer-treatment funding ecosystem, engaging with NICE and NHS England to realise a yes, no or conditional arrangement.
How can oncology treatments achieve a positive NICE appraisal in the new world and what will the mechanics of RWE be in the event of conditional funding via the reformed cancer drugs fund?
New measures proposed by the Government will impact community pharmacies across the UK; the biggest change of this nature in decades. The impact will go beyond community pharmacies as other stakeholders also feel the pressure.
UK pharmacies already support more inhabitants per pharmacy than other major European markets; how will this funding change impact how patients are cared for in the community? How will pharmacy suppliers, such as consumer health companies, operate in the increasingly cost constrained and competitive environment?
Working with our partner, IMS Health, we present an interactive webinar to share market insight on the potential impact and a live discussion with critical stakeholders of this change. Hear directly from key stakeholders about their thoughts of how the changes will play out, and what this means for you in your sector.
The pharmaceutical industry is one of the largest contributing industries to the UK’s balance of trade, and the UK Nation Health Service (NHS) is the fifth largest employer in the world.
Although the process of exit for the UK from the EU has now to be triggered by invoking article 50, the post-Brexit calendar is a firestorm of uncertainty. The uncertainty could potentially have a chilling effect on global pharma investment in the UK, but are the issues that will impact Pharma - a jewel in the crown of UKPLC - being heard in Westminster - and Brussels?
In order to better understand the potential impact of Brexit on both pharma and healthcare in the UK, we are working with specialist IMS Health to bring a unique debate in which a hand-picked panel of experts will discuss and analyse:
The impact of Brexit on UK Healthcare
The ramification of Brexit for pharma in the UK
What does the Brexit scenario mean for global pharma?
Sanofi Pasteur MSD is transforming its commercial organisation and remodeling its approach to customer engagement. Hear from Sanofi Pasteur MSD’s Alexandre Gultzgoff, Deputy Director, IT, and Antoine Blanc, Commercial Excellence Director, as they share first hand insights on how they are transforming their European commercial operations and improving customer engagement. Learn from their best practice as they share Sanofi Pasteur MSD’s:
· Vision and strategy for digital transformation
· Digital channels (CLM, email) to improve customer engagement
· Deployment of a digital supply chain in ensuring fresh content to channels and content reuse
This webinar will delve into the challenges that pharma face when looking at their patient-centricity strategy, and the opportunities that exist with this approach. We will explore the key motivators for this approach, and steps to overcome the internal and external barriers, and most importantly – how do pharma companies know when they have become truly patient-centric? How should they measure the impact of their strategy through the lifecycle of a drug and their business as a whole?