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Medical Research

  • 2018 Frost & Sullivan Predictions and Outlook for Digital Health
    2018 Frost & Sullivan Predictions and Outlook for Digital Health Daniel Ruppar, Global Program Director, Analysts from Frost & Sullivan's Global Digital Health Team Recorded: Feb 22 2018 51 mins
    Expert Insights You Will Not Want to Miss:

    • Hear market predictions from world-renowned analysts
    • Learn areas of growth and controversy for 2018 in digital health and health IT
    • Discussions on hot areas including AI, Digital Therapeutics and Blockchain
    • Movements of major ICT and Technology companies in their Healthcare strategy
    • Understand the critical vendors to watch for this year
  • Lighten Up!  Long-term imaging with ultra-bright, organic AIE cell trackers
    Lighten Up! Long-term imaging with ultra-bright, organic AIE cell trackers Liu Bin, PhD,Department Head - Department of Chemical and Biomolecular Engineering, National University of Singapore Recorded: Feb 22 2018 31 mins
    With the recent discovery of a special class of organic compounds with aggregation-induced emission (AIE) characteristics, new opportunities have opened for in vitro and in vivo imaging. In combination with advanced polymer encapsulation technologies, AIE compounds are now available as LuminiCell ultra-bright, organic nanoparticles that enable long-term cell tracking and imaging for applications such as cancer research and stem cell biology.
  • How Nanotech IP is influencing the whole semiconductor industry
    How Nanotech IP is influencing the whole semiconductor industry Dr.Shafiq Kabir CIO of Smoltek AB and Ruta @ PatSnap Recorded: Feb 21 2018 36 mins
    Many companies have influence in markets because they make essential products. Think about the products all around us the metals, plastics and various other materials that make up our world. We can see how a change in manufacturing processes or supply could influence the whole industry.

    We are joined by Dr.Shafiq Kabir, Chief Innovation Officer at Smoltek AB, to learn how companies who rely on only Intellectual Property are working to change the market. Smoltek specialises in nanomaterials and their applications and brings together industry, intellectual property and manufacturers together.

    This is essential viewing for anyone interested in nanomaterials/nanotechnology, IP, licensing and market penetration.
  • The Editor’s Black Box: Insight to the Editorial team - India
    The Editor’s Black Box: Insight to the Editorial team - India Dr Andrew Moore, EiC, BioEssays and Wiley Researcher Academy and Lou Peck, Wiley Author Marketing Recorded: Feb 21 2018 61 mins
    Find out more about the workings of a busy Editorial team of a research journal and gain invaluable insight into what drives editorial decisions of all natures connected with a manuscript.

    Register for our FREE webinar and you will receive guidance and insight about:

    - As the author what happens to your manuscript once you submit it?
    - What are the principles guiding editorial decision making?
    - What are the deciding factors when it comes to submitting a manuscript for peer review?
    - How are reviewers selected?
    - How do editors make the final decision for submission?
  • Need to judge your product? Use HPTLC to get insights into sample composition-S2
    Need to judge your product? Use HPTLC to get insights into sample composition-S2 Melanie Broszat, PhD CAMAG, Muttenz, Switzerland & Michaela Oberle Merck KGaA, Darmstadt, Germany Recorded: Feb 20 2018 56 mins
    Thin-Layer Chromatography has been a well-known method for analysis of botanicals and other complex samples since the end of the 1930s. Today’s modern thin-layer chromatography combines the advantage of analytical robustness and high sample throughput with the possibility to use all kind of specific detection methods, e.g. classical UV/Vis/Fluorescence detection, mass spectrometry or effect-directed analysis. This method increases the amount of information for a fast and efficient screening for new compounds and the identification of raw materials especially for samples with a high matrix load such as herbal drugs, cosmetic and food samples.
    HPTLC, the most advanced form of Thin-Layer Chromatography, is a powerful yet simple and cost effective tool for testing identity, purity, and strength (content) of botanicals as well as excluding adulteration during quality control. With the publication of general chapters by the United States Pharmacopoeia (USP ) and European Pharmacopoeia (Ph.Eur. 2.8.25) HPTLC has officially come into existence as a highly standardized and therefore reproducible analytical technique. The use of high performance plates, suitable instrument and software, a standardized methodology, and validated methods ensures reliable results that are fully compliant with current Good Manufacturing Practice (cGMP). HPTLC fingerprints allow convenient visual comparison of multiple samples even if those originate from different plates (and different laboratories worldwide). Reference images (HPTLC fingerprints of botanical reference materials or other references) can be used to qualify data and pass/fail samples based on similarity or difference.
    We will give you an overview about the versatility of HPTLC, applicable to many of your analytical tasks. Don’t miss the chance to extend your knowledge!
  • Need to judge your product? Use HPTLC to get insights into sample composition
    Need to judge your product? Use HPTLC to get insights into sample composition Melanie Broszat, PhD CAMAG, Muttenz, Switzerland & Michaela Oberle Merck KGaA, Darmstadt, Germany Recorded: Feb 20 2018 52 mins
    Thin-Layer Chromatography has been a well-known method for analysis of botanicals and other complex samples since the end of the 1930s. Today’s modern thin-layer chromatography combines the advantage of analytical robustness and high sample throughput with the possibility to use all kind of specific detection methods, e.g. classical UV/Vis/Fluorescence detection, mass spectrometry or effect-directed analysis. This method increases the amount of information for a fast and efficient screening for new compounds and the identification of raw materials especially for samples with a high matrix load such as herbal drugs, cosmetic and food samples.
    HPTLC, the most advanced form of Thin-Layer Chromatography, is a powerful yet simple and cost effective tool for testing identity, purity, and strength (content) of botanicals as well as excluding adulteration during quality control. With the publication of general chapters by the United States Pharmacopoeia (USP ) and European Pharmacopoeia (Ph.Eur. 2.8.25) HPTLC has officially come into existence as a highly standardized and therefore reproducible analytical technique. The use of high performance plates, suitable instrument and software, a standardized methodology, and validated methods ensures reliable results that are fully compliant with current Good Manufacturing Practice (cGMP). HPTLC fingerprints allow convenient visual comparison of multiple samples even if those originate from different plates (and different laboratories worldwide). Reference images (HPTLC fingerprints of botanical reference materials or other references) can be used to qualify data and pass/fail samples based on similarity or difference.
    We will give you an overview about the versatility of HPTLC, applicable to many of your analytical tasks. Don’t miss the chance to extend your knowledge!
  • Get Published: Your How to Guide - Latin America
    Get Published: Your How to Guide - Latin America Dr. Gwen Taylor, Peter Creaton, Brian Collins and Eduardo Martinez Recorded: Feb 15 2018 56 mins
    Join us for the first webinar in the Wiley Learn to Publish series and learn all you need to know to publish your next article with confidence. Learn from and interact with top editors in the research community during the live Q&A sessions.

    Register for the first FREE webinar now and you will receive guidance from expert editors on:

    • Selecting the RIGHT journal – How to choose the best outlet for your research
    • Preparing your article – How to follow author guidelines
    • Creating a title and abstract - How to communicate your research effectively

    Future webinars will include 'Peer Review and Publishing Ethics - the dos and don'ts' and 'Sharing and Promoting your Research - SEO and Altmetrics'.

    Attend all three webinars to receive your free ‘Get Published’ eBook and course completion certificate.
  • 5 ways to successfully commercialise your intellectual property
    5 ways to successfully commercialise your intellectual property Annelie Viksten from AWAPatents | Carol David Daniel from City University | Duncan Clark from PatSnap Recorded: Feb 14 2018 59 mins
    In this webinar, PatSnap will be joined by Annelie Viksten, Carol David Daniel and Duncan Clark to explore what ingredients are needed to create an environment that promotes the best possible chances of market success for new projects.

    Other discussion points include:

    - The importance of a fully integrated, end to end commercialisation strategy
    - How to identify the differences between projects that create new revenue, versus those that don't.
    - How to extract more ROI from your existing intellectual property
    - Understanding the difference in approaches to innovation in academia, and the commercial world.
  • Efficient execution of biologics manufacturing – The role of Finite Scheduling
    Efficient execution of biologics manufacturing – The role of Finite Scheduling Gloria Gadea-Lopez, Ph.D., John Maguire and Megan Rabideau Recorded: Feb 14 2018 47 mins
    The success of manufacturing relies on the availability of all the resources –personnel, materials, equipment, work instructions - , orchestrated in such a way that the operations proceed in an efficient and predictable manner. This article describes the implementation of a finite scheduling system for biologics production, the foundational work required prior to project launch, lessons learned, and benefits achieved from this deployment.
  • An introduction to best practices for refereeing a journal manuscript
    An introduction to best practices for refereeing a journal manuscript Professor Simon Cherry, University of California, Davis, USA Recorded: Feb 13 2018 45 mins
    Peer review is one of the most critical components of high-quality scientific publishing. It impacts on the timeliness, accuracy and clarity of research findings that—if published—will be accessible and visible to everyone for years to come.

    At its best, the peer-review process establishes whether the work makes a genuine and valuable contribution to the literature, and can remove errors and help authors to better explain their results and the significance of their work to the broad audience who may read the final journal article. At its worst, however, inadequate or superficial peer review can allow substandard work or poorly explained research to be published, which is to the detriment of the scientific enterprise. In addition, the peer-review process can also impede the publication of high-quality work through unnecessary delays or personal bias.

    The goal of this webinar is to address best practices for reviewing a journal manuscript and address some of the challenges and pitfalls that frequently crop up during the peer review process. This webinar is aimed at those new to serving as a referee for a scientific journal – whether that be more generally, within the field of medical physics, or for Physics in Medicine & Biology specifically.
  • Disposables – Suitability and Process Economy In Biopharmaceutical Manufacturing
    Disposables – Suitability and Process Economy In Biopharmaceutical Manufacturing Dr Joachim Walter Recorded: Feb 8 2018 38 mins
    Since the introduction of disposables and gaining popularity of Single-use Technology (SUT) for biopharmaceutical manufacturing there is nevertheless an ongoing controversial discussion on the advantages and disadvantages versus a conventional stainless steel environment.

    In a “classical” facility design any validation cost effort can easily be distributed to a considerable number of production runs thus contributing only to a non-decisive amount to the overall production costs. The scale for such plant is nearly unlimited as is the scale of operation. The “flexible” approach using disposables and single-use equipment offers significant advantages regarding changeover work and time thus a high throughput of different processes will definitely take profit as any cleaning and related validation and costly analytics doesn’t apply to a larger extent.

    Despite the potential benefits loudly advertised by the respective industry, these potential advantages derived from single-use equipment and disposables can be significantly diminished by lack of detailed process cost analysis, missing economic analysis and cost comparison between conventional and SU technologies as well as underestimating the cost of long term dependency on consumables. Due to missing appropriate standards, there is a widely non-compatibility between the equipment and consumables of the various suppliers, resulting in a strong dependence on the consumables of a single supplier once a single-use equipment has been purchased, curiously leaving some customers with surprise that they hardly have any room for price negotiations on the required consumables.
    This paper’s focus is on the very different arguments for the application of SU equipment and consumables, including advantages and limitations of SUT, understanding improvement of process robustness, contribution to lean production as well as environmental impact of disposables.
  • Building a Data Forever Architecture
    Building a Data Forever Architecture Erik Ottem, Director Product Marketing, Western Digital Recorded: Feb 6 2018 27 mins
    Unstructured data has evolved into a business asset, creating the need to keep more data longer. The growth and diversity of unstructured, in the form of large media files, metadata, and complex business documents have created a strain on traditional storage infrastructures and IT budgets.

    In this webinar, our industry expert Erik Ottem will discuss the expanding role of unstructured data, the shortcomings of traditional storage architectures and the building blocks to capture, store and preserve data at scale and throughout its entire lifecycle.

    Register today and learn how to build a data forever architecture so your data can become a competitive advantage rather than a burden.
  • Do Extractable Protocols Truly Help- An End User Perspective
    Do Extractable Protocols Truly Help- An End User Perspective Ekta Mahajan, Genentech/Roche Recorded: Feb 5 2018 66 mins
    Single Use technology is being used more each year in the biotechnology industry. However, extractables and their potential impact on product and patients continue to be one of the biggest challenges. The challenge is augmented by the lack of standardized methodology for suppliers to execute extractable studies that meets end user requirements. The end users are responsible and required by law to assess the impact of extractables and leachables on overall Product Quality and Safety. Due to lack of a standard, customized data had to be generated for/by each end users. This resulted in long lead times, higher costs and inefficient utilization of resources. Typically, the data generation and qualification of single use component can take up to a year, which can impact implementation of single use. BioPhorum Operations Group (BPOG) developed a standardized protocol9 for generating extractable data that would meet user requirements and simplify/reduce implementation time within industry. A standardized protocol gives confidence to suppliers that testing performed by them would meet end user requirements and enable faster implementation. Some suppliers shared the BPOG vision and proactively tested their single use components using BPOG protocol, which has helped expedite the use of their products.
  • Venezia – Reaching Beyond
    Venezia – Reaching Beyond Matthew Biagioli, MD Recorded: Feb 5 2018 61 mins
    Treating advanced-stage cervical cancer can be difficult without the right tools. Dr Matthew Biagioli will discuss a new option for reaching beyond the current constraints with the Venezia applicator for reproducible results and seamless integration into your current workflow.
  • Sharing and Promoting your Research- Wiley Learn to Publish Webinar Series
    Sharing and Promoting your Research- Wiley Learn to Publish Webinar Series Jennifer Deroche and Katy Dillon Recorded: Jan 31 2018 24 mins
    Maximise the impact of your published work! Find out more about sharing and promoting your research including SEO and Altmetrics.

    In the third and final webinar in our Learn to Publish series, our expert editors and marketers will cover:
    -What you need to do to get read, get shared and get cited
    -SEO in 4 easy steps
    -Title, Abstract and Keyword best practices
    -Tips for building links
    -Understanding Impact Factors and Altmetrics
    -Tools and resources available to help you share and promote your work
    We’ll also be answering your questions in a live Q&A.
  • Need to validate your genome editing experiment? LentiORF to the rescue!
    Need to validate your genome editing experiment? LentiORF to the rescue! Stacey Ward, PhD Recorded: Jan 24 2018 47 mins
    Whether you are looking to perform gene overexpression studies or validate gene knockdown/knockout results from your RNAi/CRISPR experiments, LentiORFs are your ideal shortcut to protein expression and gene analysis. These genes are available in either pooled or arrayed libraries, and can also be combined into gene family sets and custom clone panels to meet diverse research needs. They are excellent reagents for gain-of-function screens and are a powerful complement to CRISPR and RNAi. In this webinar, we will introduce the LentiORF library and its various formats. We will discuss the application of this technology as it pertains to experimental design, delivery mechanisms, data analysis and target validation. Further, we will present recent data demonstrating clone representation of the library in each of its available formats, along with functional validation of the viral particles at the level of both viral integration and functional RNA expression.

    Our ready-to-use Mission TRC3 LentiORFs allow for stable integration, enrichment of cells, and long-term gene expression in difficult-to-transfect cell lines utilizing our best-in-class lentiviral manufacturing. This collection provides researchers with unique tools to gain insights into gene function by modulating gene and protein expression.
  • The Picture Perfect Future of the US Medical Imaging Industry
    The Picture Perfect Future of the US Medical Imaging Industry Frost & Sullivan Transformational Health Team, Shannon Werb, vRad Recorded: Jan 23 2018 62 mins
    The US medical imaging industry is transforming to cope with the challenges of the present and the demands of the future. The current care provision landscape is highly fragmented, and a coherent strategy is required to enhance interoperability among stakeholders across the imaging ecosystem. Stakeholders across the industry must also come together to eliminate redundancies and duplications, and streamline the imaging process, to improve the patient experience.
  • Publishing Ethics: understanding the dos and don’ts of research publishing
    Publishing Ethics: understanding the dos and don’ts of research publishing Dr Andrew Moore Recorded: Jan 22 2018 47 mins
    Learn more about what happens once your research article submission has been accepted
    •What are the author’s responsibilities?
    •What do ethics in publishing looking like?
    •What constitutes ethical misconduct?
    •How do ethics support authors?
    •What are the golden rules?

    Join us for our live webinar clinic and learn all you need to know about publishing ethics, what they are, why they exist and how to successfully navigate through them.
    Plus a chance to interact with the Editor-In-Chief for the Wiley Researcher Academy, Dr Andrew Moore and ask any further questions about the platform during the live Q&A sessions and connect with other researchers in the BrightTalk community.

    Register for our FREE webinar now and you’ll receive guidance on:
    •Ethics within scientific publishing
    •Your roles and responsibilities
    •What support and guidance tools are available
    •Navigating ethical challenges
    •The dos and don’ts of research publishing
  • Introduction to searching/using Markush structures from Patents
    Introduction to searching/using Markush structures from Patents Roshan Jumnah and Ruta Sudmantaite @ PatSnap Recorded: Jan 17 2018 34 mins
    Chemical Patents are often very long and difficult to read. Markush searching can enable you to easily categorize and filter the information you need, giving you the insights that a paper sometimes cannot.

    In this webinar you will learn:

    -How to get started with patent search
    -Basic patent language you need to be aware off
    -How to create Markush searches to yield the best results when researching.
    -Benefits of patent search for your processes
  • Enabling comprehensive data analytics and process monitoring in Biomanufacturing
    Enabling comprehensive data analytics and process monitoring in Biomanufacturing Robert Dimitri and Gloria Gadea-Lopez, Ph. D Recorded: Jan 17 2018 48 mins
    Technical teams rely on the availability of meaningful data and effective tools to perform process monitoring, to conduct root cause analysis and investigations and, most of all, to obtain new insights into their operations. In this article, the authors discuss the implementation and management of a comprehensive system for data analytics at Shire –Lexington, MA site, the lessons learned, and practical advice towards the successful deployment of these key applications.
  • Estimating respiratory rate from the electrocardiogram and photoplethysmogram
    Estimating respiratory rate from the electrocardiogram and photoplethysmogram Dr Peter H. Charlton Research Associate, King’s College London Recorded: Jan 16 2018 44 mins
    Respiratory rate (RR) is a key physiological parameter that is used in a range of clinical settings for diagnosis and prognosis. Despite its importance, it is usually measured by hand. Over the past 50 years many techniques have been developed to estimate RR from two widely acquired physiological signals: the electrocardiogram (ECG) and the pulse oximetry signal (photoplethysmogram (PPG)). Although these techniques have been the subject of much research, they have not yet been widely integrated into clinical practice. This webinar will provide a comprehensive overview of the state of the art in estimating RR from the ECG and PPG. It is intended to equip researchers with the knowledge and tools to translate this promising technology into patient benefit.
  • Current and future applications of Near-infrared in Pharmaceutical and Biopharma
    Current and future applications of Near-infrared in Pharmaceutical and Biopharma Dr Erik Skibsted 7 Dr Fabien Chauchard Recorded: Jan 10 2018 68 mins
    Near-infrared has a long tradition as analytical technology in pharmaceutical industry. In this article/webinar new applications, technology and improvements in regulatory guidances will be presented which will support further growth of nearinfrared in the pharmaceutical and biopharmaceutical industry.
  • Plan Explorer; An Automated Treatment Planning Approach
    Plan Explorer; An Automated Treatment Planning Approach Björn Hårdemark, Deputy CEO, RaySearch Laboratories Recorded: Dec 20 2017 61 mins
    Plan Explorer provides a new paradigm in treatment planning. This talk goes through the underlying algorithms, explains how to use the system, gives examples of plan configurations and provides an outlook into future developments of this feature found within the RayStation treatment planning software.
  • Digitizing Clinical Research Processes - The New Frontier
    Digitizing Clinical Research Processes - The New Frontier Cedars-Sinai's Research Manager, Jenny Lester, and Associate Director, Therica Miller Recorded: Dec 18 2017 58 mins
    Clinical trial enrollment and site initiation is often hindered by cumbersome onboarding paperwork, delaying clinical research and R&D investments. The good news? Cedars-Sinai's Research Manager, Jenny Lester, and Associate Director, Therica Miller have solved the issue by going digital, leading to accelerated processes and greater compliance with regulations like 21 CFR Part 11.

    Watch this on-demand webinar now and learn how to:

    -Overcome challenges in clinical site initiation & maintenance
    -Implement a pilot to test effectiveness of new digital processes
    -Identify and activate use cases for digital investment
  • Everything You Need to Know About Critical Healthcare Segments
    Everything You Need to Know About Critical Healthcare Segments Sanjeev Kumar (Industry Manager), Natasha Gulati (Industry Manager), Siddharth Shah (Industry Analyst) Feb 27 2018 6:30 am UTC 135 mins
    Frost & Sullivan is forecasting another year of disruptions in critical healthcare segments such as diabetes care, smart hospitals, healthcare cloud computing and digital pathology. This webinar will focus on these industries along with insights on key trends influencing the healthcare system, followed by a live question-and-answer session.

    Join Us to Gain Insights on:

    • Future paradigms in diabetes care and harnessing evolutionary trends to improve the quality of life for diabetics
    • Understanding the smart hospital concept and identifying relevant applications and growth opportunities
    • Healthcare cloud computing trends, such as global provider spending on cloud solutions approaching $10 billion by 2021
    • Growth opportunities in the global digital pathology market
  • HGST SVR2U24 NVMe Storage Server
    HGST SVR2U24 NVMe Storage Server Manfred Berger, HGST - Sr. Mgr. Business Development Platforms EMEAI Feb 27 2018 10:00 am UTC 45 mins
    In this webinar Manfred Berger introduces the latest addition to the HGST platform portfolio, the SVR2U24 NVMe all-flash storage server.

    Combining high performance NVMe SSDs and Intel®’s Purley server architecture into one tried and tested unit, the SVR2U24 enables customers to come to market quickly with a multitude of software defined storage solutions or data base servers optimized for high speed search operations, catering to a multitude of industry verticals.
  • Modelling the Thermoelectric Effect
    Modelling the Thermoelectric Effect Andrew Young, Technical Manager, COMSOL Feb 28 2018 2:00 pm UTC 60 mins
    If you want to learn how to simulate the thermoelectric effect in the COMSOL Multiphysics® software, then tune into this webinar.

    The thermoelectric effect, which involves the reversible conversion between heat and electricity, is a phenomenon that is used in both heating and cooling applications. The effect is often used in devices such as thermal sensors, energy harvesters and Peltier coolers.

    In this webinar you will learn how to model the coupled phenomenon in COMSOL Multiphysics®. We will discuss the basic theory for heat transfer and electric currents as well as highlight how to account for the Peltier, Seebeck and Thomson effects. During a live demonstration these effects will be combined in a single model.

    This webinar includes a Q&A session during which you can ask questions.
  • Functional collaborations required to successfully validate a Mab process at a C
    Functional collaborations required to successfully validate a Mab process at a C Harish Santhanam Feb 28 2018 3:00 pm UTC 75 mins
    Technology transfer leading to a successful validation of a Monoclonal Antibody process at a CMO site is a complex task that would need seamless interaction between various functions of the sending and receiving organizations. The success of the process is very much dependent on the technical depth, personal trust and the strength of the relationships established between the team members across the various functions in both organizations. The interactions begin with the due diligence process and builds through laboratory scale technology transfer leading to engineering/GMP campaigns and ends with a successful validation.  Depending on the stage in development of the molecule being technology transferred, the sending organizations could have personnel involved from both development and manufacturing making the process more complex. This write up will outline the role played by the various functions starting from Technical Services to Quality Assurance and will include functions like Shipping and Supply Chain.
  • Making patent searches more effective with Boolean
    Making patent searches more effective with Boolean Dvorah Graeser from KISSPatents and Ruta Sudmantaite @ PatSnap Feb 28 2018 4:00 pm UTC 45 mins
    Patent searching is something most IP counsel is very familiar with. It's your day to day when looking at Freedom to Operate, competitive analysis and portfolio management.

    However, it can be hard to predict what you need in a search when you are not a technical expert. In this webinar, we will teach you how to construct the most effective searches using boolean and a few other tips and tricks on how to ensure you include all the technical detail you need.
  • Process analytical Technology for Upstream Bioprocessing
    Process analytical Technology for Upstream Bioprocessing Erica Fratz-Berilla & LCDR Agarabi Mar 5 2018 3:00 pm UTC 75 mins
    In commercial cell culture bioprocessing, consistent high quality protein is a fundamental goal that is typically accomplished during development through product and process engineering of bioreactor parameters. The FDA’s Center for Drug Evaluation and Research (CDER)’s Office of Biotechnology Products’ upstream bioprocessing laboratory, a part of the Office of Pharmaceutical Quality’s Center of Excellence (COE) in Manufacturing Science and Innovation, studies Process Analytical Technology (PAT) for upstream bioprocessing, focusing on the production of monoclonal antibodies. These capabilities are being leveraged to study continuous bioreactor cell culture production and compatible PAT tools. Case studies are presented that illustrate collaborative laboratory research being conducted on PAT tools for upstream bioprocessing to support regulatory decision making.
  • Application of Multivariate Data Analysis for Process Diagnostic and Root Cause
    Application of Multivariate Data Analysis for Process Diagnostic and Root Cause Ramila Peiris, Ph.D., Manager, Process Modelling and Process Analytical Technology, Sanofi Pasteur Mar 7 2018 3:00 pm UTC 75 mins
    The utilization of Multivariate Data Analysis (MVDA) techniques at Sanofi Pasteur, Toronto site has demonstrated innovative capabilities for improved process understanding, control and diagnostics. Examples from several successful and high impact applications will be presented. These examples cover the application of MVDA techniques in multivariate process control, root cause investigations and process analytical technology (PAT). The areas of application include fermentation, downstream purification and product formulation stages.
  • NanoRaman: Correlated Tip-Enhanced Optical Spectroscopy and SPM
    NanoRaman: Correlated Tip-Enhanced Optical Spectroscopy and SPM Dr Marc Chaigneau, AFM/Raman product manager Mar 8 2018 3:00 pm UTC 60 mins
    Raman spectroscopy and confocal Raman microscopy have already proved to be essential characterization tools in many areas of advanced research, with a number of these applications extending into industry. As time moves on, new applications that are not addressed by existing technologies arise. Indeed, at the nanoscale, materials exhibit different properties than at the macro level, often quite dramatically different. The characterization of nanomaterials naturally requires imaging techniques with resolution at the same scale or better, so that local property variations can be discerned and defects properly detected; only with this understanding can the material properties be engineered to meet the performance requirements of next-generation devices.

    In this webinar, HORIBA Scientific, the world leader in micro and nanoRaman spectroscopy, will present new nano-imaging capabilities. Tip-enhanced optical spectroscopies (TEOS) such as TERS (tip-enhanced Raman spectroscopy) and TEPL (tip-enhanced photoluminescence) provide a unique capability for the characterization of diverse 0, 1 and 2D materials. We will demonstrate the power and importance of the cross-correlation of nanoscale hyperspectal imaging with data from other scanning-probe techniques such as topography, surface potential, conductivity and photocurrent. We will also discuss how we have extended this technique to other nano-materials as well as semiconducting nanostructures and bio-materials.
  • Project and Portfolio Management as a key tool to manage continuous improvement
    Project and Portfolio Management as a key tool to manage continuous improvement Gloria Gadea-Lopez, Ph.D.and Melvin Santos Mar 14 2018 2:00 pm UTC 75 mins
    Continuous improvement, risk mitigation and adherence to compliance rely on the successful execution of key initiatives aligned with an organization’s strategic imperatives. This article summarizes the Project and Portfolio initiatives at Shire’s Biologics manufacturing facility at Shire, Lexington, MA site. In addition to practical advice, the authors discuss the need for sound business processes, alignment with Finance and budget cycles, and play special attention to the importance of resource allocation and management.
  • Genome Editing in Plants with CRISPR/Cas9: Design to Validation
    Genome Editing in Plants with CRISPR/Cas9: Design to Validation Casey Jowdy, PhD CRISPR Product Specialist Genome Editing Tools Mar 14 2018 3:00 pm UTC 75 mins
    The CRISPR/Cas genome editing system has revolutionized almost every aspect of the life science industry. This exciting method is rapidly advancing fundamental plant research, and plant biotechnology. In this webinar, we introduce strategies for gene editing in plants with our portfolio of CRISPR/Cas9 plant vectors and discuss the application as it pertains to experimental design, delivery mechanisms, and target validation.
  • Nano- and Microfabricated Hydrogels for Regenerative Engineering
    Nano- and Microfabricated Hydrogels for Regenerative Engineering Ali Khademhosseini, PhD Mar 15 2018 3:00 pm UTC 90 mins
    Engineered materials that integrate advances in polymer chemistry, nanotechnology, and biological sciences have the potential to create powerful medical therapies. Our group aims to engineer tissue regenerative therapies using water-containing polymer networks, called hydrogels, that can regulate cell behavior. Specifically, we have developed photocrosslinkable hybrid hydrogels that combine natural biomolecules with nanoparticles to regulate the chemical, biological, mechanical and electrical properties of gels. These functional scaffolds induce the differentiation of stem cells to desired cell types and direct the formation of vascularized heart or bone tissues. Since tissue function is highly dependent on architecture, we have also used microfabrication methods, such as microfluidics, photolithography, bioprinting, and molding, to regulate the architecture of these materials. We have employed these strategies to generate miniaturized tissues. To create tissue complexity, we have also developed directed assembly techniques to compile small tissue modules into larger constructs. It is anticipated that such approaches will lead to the development of next-generation regenerative therapeutics and biomedical devices.
  • Integration of Disposable Components into Traditional Stainless-steel Facilities
    Integration of Disposable Components into Traditional Stainless-steel Facilities Ron Bates, Bristol-Myers Squibb Mar 19 2018 2:00 pm UTC 75 mins
    This presentation will analyse the benefits and limitations associated with the implementation of single-use technology at a large-scale, multi-product commercial manufacturing facility. By integrating single-use components into a stainless steel facility, a hybrid equipment approach enhances manufacturing flexibility while enabling an accelerated manufacturing cadence.
  • SUS Leachable Testing: Leachable Study Design for Single-Use Components
    SUS Leachable Testing: Leachable Study Design for Single-Use Components Kathryn McGohan Mar 20 2018 2:00 pm UTC 75 mins
    The BPOG Leachables Working Group has recently published a Best Practice Guide for Leachables. The Best Practice Guide was developed to help Biopharmaceutical and Vaccines Manufacturers to develop science-based, robust, and efficient approaches to handling the risk of leachable compounds that is associated with increasing use of Single-Use Systems in manufacturing processes. The Best Practice Guide is composed of three parts: the risk assessment model, leachable study design, and analytical methods. This article provides insight into the application of the Best Practices for Leachables Study Design by end users and will include a case study to highlight the importance of the study design.
  • How can pharma support a more collaborative NHS through STPs and ACSs?
    How can pharma support a more collaborative NHS through STPs and ACSs? Stephen Dorrell, NHS Confederation, James Roach, Accountable Care Partnership, Essex Andrew Smith, Cobic, Steve Jowett, IQVIA Mar 21 2018 12:30 pm UTC 60 mins
    Is your company prepared for the changes in the NHS, and is it aware of pharma’s potential to play a leading role in transforming services?

    Over the last few years, the government has been trying to reshape the NHS by making it more responsive to the health needs of regional populations. By dividing England’s NHS into 44 Sustainability and Transformation Partnerships (STPs), policymakers hoped to promote new care models by forging links between NHS, councils and other stakeholders.

    These are now evolving into Accountable Care Systems (ACSs), involving closer collaboration between the key players, including the private sector and pharma. This system change has been controversial, with critics saying that it is tantamount to privatisation by the back door. But champions of ACSs say that it can improve governance and commissioning outcomes and create a health system that is matched to the population it serves.

    This IQVIA/pharmaphorum webinar gives an update on the latest developments and asks how pharma can be a catalyst for change at a time when the NHS is under immense pressure to cut costs and become more efficient.

    Watch this interactive digital debate and:
    •Learn more about the STP/ACS model of delivery
    •Find out what is needed to set them up successfully
    •Discover the role of data in delivering STP/ACS models
    •Understand the importance of STP/ACS models for pharma
  • DSF and FTIR as methods for the identification and characterization
    DSF and FTIR as methods for the identification and characterization Marina Kirkitadze and Kristen Kalbfleisch Mar 21 2018 2:00 pm UTC 75 mins
    The focus of this presentation is the application of Fourier Transform Infrared Spectroscopy (FTIR) and Differential Scanning Fluorimetry (DSF) methods to characterize vaccine components and their stability. Additionally, FTIR can be applied for the identification of final vaccine products, and DSF can be used to distinguish different formulations of vaccine candidates. These methods, when used in conjuction, provide valuable information regarding characterization and stability in the final stages of vaccine manufacturing.
  • Tomotherapy planning in RayStation
    Tomotherapy planning in RayStation Misty Lehman-Davis CMD, BS, RT (R)(T), Senior Application Specialist, RaySearch Americas Mar 22 2018 4:00 pm UTC 60 mins
    Tomotherapy planning was added into RayStation software in December 2016 as part of the V6 release. This addition allows a seamless planning approach for centers with helical Tomotherapy combined with conventional linacs. For the first time ever, all planning can be done within one treatment planning system. RayStation’s advanced planning modules such as Multicriteria Optimization are well suited for Tomotherapy planning and will be shown. Finally, there are some unique features to the Tomotheraphy optimization that will be described by our in-house expert.
  • Accelerating Research Innovation with Next-Gen Storage Infrastructure
    Accelerating Research Innovation with Next-Gen Storage Infrastructure Vas Vasiliadis, Chief Customer Officer, Globus Mar 22 2018 5:00 pm UTC 45 mins
    For research data to be truly useful, it must be easy to access, share and manage without requiring expensive, custom infrastructure. What organizations need is turnkey storage that won't break the bank, with a unified interface for fast, reliable data transfer and sharing.

    This webinar introduces Globus for ActiveScale, a cost-effective solution for on-premise object storage that’s simple to deploy and use. With Globus for ActiveScale, researchers have access to advanced capabilities for managing data across a broad range of systems, while administrators gain a cost-effective, scalable, and durable solution they can deploy quickly to help their researchers innovate faster.

    In this webinar, attendees will:
    - Learn how to deploy and use Globus for ActiveScale
    - See a product demonstration
    - Engage in a live Q&A session with the Globus Chief Customer Officer
  • Basics of Immunohistochemistry
    Basics of Immunohistochemistry Jeff Gordon, OEM Sales, Merck KGaA, Darmstadt, Germany Mar 30 2018 3:00 pm UTC 75 mins
    Immunohistochemistry is the technology of detecting cellular and infectious agent proteins in tissue with antibodies and then labeling those antibodies with a chromogen so that they are detectable under a light microscope. This science has become a standard method in diagnostics for classifying neoplasms and detecting infectious microbes. The science and technique behind immunohistochemistry are discussed in this webinar.
  • Filtration in Dissolution Testing: Improving Throughput and Reducing Variability
    Filtration in Dissolution Testing: Improving Throughput and Reducing Variability Vivek Joshi, Ph.D. Apr 2 2018 3:00 pm UTC 75 mins
    In vitro dissolution testing is used to characterize drug compounds throughout their development. In early drug development it is used to support the choice of a particular formulation. During drug production it is a critical component of the quality control process and is used to assess the changes in manufacturing processes or formulation. In order for dissolution results to be meaningful at each stage, the test and the process need to be reliable, consistent, predictive and accurate.

    Filtration as the only sample preparation step plays an important role in the dissolution process, yet this step is often taken for granted. The choice of frits or syringe filters is often based on experience with previous formulations or availability in the lab. Selecting the wrong filter can result in inadequate filtration, low analyte recovery, solvent incompatibility or extractables that reduce accuracy and reproducibility. The wrong pore size or device can result in clogging that can adversely affect throughput and sample processing.

    This seminar describes different membrane characteristics and provides guidance in selecting the right filtration devices for sample preparation following in vitro dissolution. Problems that result from using the wrong filter are presented along with steps one can take to solve each problem. Filter characteristics that affect drug recovery and downstream analysis, such as non-specific binding and extractable levels, are presented. Steps one can take to optimize throughput and reduce downtime are addressed including a discussion on membrane properties and guidance on the use of multi-layer and automation compatible filters. Recommendations are presented for choosing the right sample preparation device that will help improve throughput, reduce sample processing time and enhance test accuracy and reproducibility.
  • Current Progress in Approaches for The Safety Assessment of E&L
    Current Progress in Approaches for The Safety Assessment of E&L Kim Li, PhD, DABT, MPH, Amgen Inc. Apr 6 2018 2:00 pm UTC 75 mins
    This Webinar will review the current progress in the risk management of extractables and leachables (E&L) impurities with focus on protein therapeutics. While toxicology assessments of E&L impurities are maturing toward best practices, their potential impact to product quality requires new approaches from the toxicologist toolbox. This webinar will discuss the in silico prediction of chemical fictional groups that pose high risk of covalent binding, potentially leading to structural modifications of proteins and impact to quality attributes.
  • Applied Analytical Techniques to Monitor IsoAsp in Biologics Formulation Develop
    Applied Analytical Techniques to Monitor IsoAsp in Biologics Formulation Develop Dominick Gerald DeGrazio, Janssen Apr 10 2018 2:00 pm UTC 75 mins
    The development of a suitable biologic formulation occurs often before analytical methods are validated. Certain chemical modifications are critical to monitor during the development process as they may cause protein instability and reduce biologic efficacy. Aspartic acid isomerization is one such modification, but is arguably the most difficult to detect. Analytical tools to track IsoAsp are discussed that can aid in making formulation decisions before the availability of qualified methods.
  • Key components of a comprehensive program for the management of single use techn
    Key components of a comprehensive program for the management of single use techn Mark Maselli Apr 19 2018 2:00 pm UTC 75 mins
    As a result of the increased adoption of single-use technologies (SUTs) in biotech manufacturing, companies need to develop and implement programmatic approaches for the management of these systems under regulatory compliance. This webinar discusses the key aspects of such programs, with emphasis on collaboration with suppliers, cost management, as well as practical insights about the use of SUTs.
  • Quality-By-Design in Spray Drying Processes - Transfer Lab to Production
    Quality-By-Design in Spray Drying Processes - Transfer Lab to Production Sune Klint Andersen, Janssen Pharmaceutica May 10 2018 2:00 pm UTC 75 mins
    Spray drying is a continuous and scalable manufacturing process commonly used in the pharmaceutical industry. Due to its scalable and continuous nature it is possible to apply Quality-by-Design (QbD) and Process Analytical Technologies (PAT) early on in the development of a spray drying process.
    Knowledge gained from QbD e.g. Design-of-Experiments (DoE) and PAT increases process understanding and the knowledge can be readily applied when scaling up the process and in production scale application of PAT i.e. especially with respect to the control strategy.
    The Webinar will discuss the application of QbD early in the development and how the obtained knowledge can be used to optimize transfer of the spray drying process to production scale including PAT strategy.
  • End User Perspective on Setting in-Process Endotoxin Limits
    End User Perspective on Setting in-Process Endotoxin Limits Dr Friedrich von Wintzingerode, Roche/Genentech May 15 2018 8:00 am UTC 75 mins
    There is a lack of detailed guidance for setting endotoxin in process limits (alert levels and action limits) for biologics. This webinar will present a concept for setting in-process  limits and a case study which allows to understand the underlying rationales and challenges.