Search results Search for: Search Refine your results by duration: Any Under 5 mins Under 20 mins Over 20 mins Sort by: Relevance Views Date Sanofi’s Journey & Strategy for Continuous Processing for Small Molecules Flavien Susanne at Sanofi and Sean Bermingham at PSE Ltd In the past decade, there has been a growing interest in the application of continuous processing in the pharmaceutical industry with 100s millions of... 4 months ago | 117 mins Charting the chemical reaction space for DNA-encoded library design Dr Andreas Brunschweiger, Professor at Chemistry and Chemical Biology of TU Dortmund DNA-encoded libraries (DELs) are a powerful technology for target-based small molecule screening. DEL design raises the question of chemical reaction ... 3 months ago | 49 mins Targeting Notch Altered Patient Derived Xenografts (PDX) with AL101 Joel Kaye, PhD, VP Research & Nonclinical Development, Ayala Pharmaceuticals Notch pathway activation has been implicated in the development of cancer. Notch cleavage by γ-secretase frees the Notch intracellular domain (NICD), ... 1 year ago | 28 mins Future Trends To Control Risks From Extractables and Leachables Presented by Jason Creasey, Managing Director at Maven E&L Ltd and Kathleen Lava PhD – E&L Expert Nelson Labs Europe Presented by Jason Creasey, Managing Director at Maven E&L Ltd Jason Creasey is a graduate Analytical Chemist. He has recently setup as an independen... 12 months ago | 105 mins ICH Q3E Guidelines and Its Implications Jason Creasey, Managing Director at Maven E&L Ltd and Dries Cardoen at Nelson Laboratories, LLC Presented by Jason Creasey, Managing Director at Maven E&L Ltd Jason Creasey is a graduate Analytical Chemist. He has recently setup as an independen... 10 months ago | 107 mins 2D Ex Vivo Patient-derived AML Platform for testing Molecular-Targeted Therapies Bandana Vishwakarma, PhD, Scientist in Hematology Oncology at Champions Oncology Champions Oncology was excited to participate in the American Association of Cancer Research’s (AACR) Virtual Meeting in June. Due the limited availab... 1 year ago | 22 mins High-Resolution Characterization of Structure, Interaction, and Miscibility Eric Munson, Professor and Head at Purdue University Full Title: High-Resolution Characterization of Structure, Interaction, and Miscibility of Drug Products The local interactions between a drug and it... 1 year ago | 59 mins The Journey to Lean Implementation for Efficiency Increase Uwe Voelker, Site Head, Sterile Drug Product Manufacturing at Roche Adoption of strategic and systematic use of lean principles to improve operational efficiencies and cost competitiveness Systematic reduction of waste... 1 year ago | 42 mins DNA-encoded libraries in drug discovery Dr. Alex Satz; Dr. Andreas Brunschweiger DNA-Encoded library (DEL) screening is now commonly used in the pharmaceutical industry to find novel chemical matter that modulates protein targets o... 1 year ago | 78 mins Early Chemical Development on BMS-986095 for Hepatitis C Virus Changxia Yuan,Senior Research Investigator, Bristol Myers Squibb and Scott Newman, Customer Consultant, Elsevier Drug development is the process of bringing a new pharmaceutical drug to the market once a lead compound has been identified through the process of dr... 1 year ago | 54 mins Cell cycle intervention beyond Palbociclib; discovery of a CDK2/4/6 inhibitor Stephen Dann, PhD, Associate Research Fellow, Pfizer Phosphorylation of the retinoblastoma protein (RB1) by cyclin-dependent kinases (CDK) 4 and 6 is a critical checkpoint for G1/S cell cycle progression... 1 year ago | 51 mins Reaxys Patent Expansion 2021: An improved Competitive Intelligence Jen Teske, Solution Sales Manager and Robert Niebergall, Customer Consultant Reaxys is growing. The leading knowledge solution for small molecule design and synthesis has exponentially augmented its patent content to bring you ... 8 months ago | 48 mins The New P&L speaks to Emma Chaffin, VP & Head of Galapagos UK Paul Spiers, Founder, The New P&L - Principles & Leadership in Business Podcast series This week, The New P&L – Principles & Leadership in Business podcast series speaks to Emma Chaffin, Vice President & Country Head, of biotech innovato... 11 months ago | 41 mins Optimizing clinical trial design with extracted efficacy data Marnix Wieffer Around 90% of the small molecule drugs that enter clinical trials do not make it to the market. Therefore, optimizing clinical trial design and reduci... 2 years ago | 46 mins Overcoming Analytical Method Development Challenges Karina Kwok, PhD, Associate Principal Scientist, Laboratory Sciences Mark Wolfe, BS, Senior Research Scientist Title: Overcoming Analytical Method Development Challenges: Analysis of Nonclinical Dose Formulations from hERG Studies Abstract: The ICH S7B guideli... 8 years ago | 37 mins Duolink in Biomedical Science, Session 2 J. Matthew Rhett, PhD Instructor, Department of Surgery, Medical University of South Carolina Gap junctions (GJs) are large aggregates of intercellular channels that facilitate the diffusion of small molecules and ions between two interacting c... 7 years ago | 52 mins Duolink in Biomedical Science, Session 1 J. Matthew Rhett, PhD Instructor, Department of Surgery, Medical University of South Carolina Gap junctions (GJs) are large aggregates of intercellular channels that facilitate the diffusion of small molecules and ions between two interacting c... 7 years ago | 55 mins Biosimilar Naming: How Could the Suffix Impact the U.S. Health System? Eric Henry, PharmD, Clinical Content Specialist with Clinical Effectiveness at Wolters Kluwer, Heath Join Eric Henry, Clinical Content Specialist focused on the domestic drug file with Clinical Effectiveness at Wolters Kluwer, Heath, in a 45-minute li... 3 years ago | 45 mins Need It, Want It, Gotta Do It: How to Optimize Your Nonclinical ADME Studies Richard Slauter, PhD, Andrew Augustine, MS, Rachel Goldsmith, PhD We all need to do Absorption, Distribution, Metabolism, and Excretion (ADME) studies to support an NDA submission, but when does ADME data best suppor... 6 years ago | 56 mins Advances in Mass Spectrometry for the Analysis and Bioanalysis of Antibody-Drug Arnaud Delobel, PhD ADCs are complex compounds resulting from the coupling of cytotoxic small molecules to a monoclonal antibody. Their characterization as well as their ... 4 years ago | 34 mins Challenges and Successes in Externalization of the ADC Supply Chain Firelli Alonso, Ph.D. Sourcing for the manufacture and control of Antibody-Drug Conjugates (ADCs) used in clinical trials requires strategic planning, establishment of a sp... 5 years ago | 74 mins How Do I Get My Compound Into Phase I? Scott Boley, PhD, DABT, Greg Ruppert, BA Careful assessment of the relationship between efficacy and toxicity is vital to drug developers as they seek advancement of their compounds. Nonclini... 5 years ago | 58 mins Visualizing DNA Methylation (5mC) on a Specific Genomic Locus (SEPTIN9) 01 Dr. Vikas Palhan, Sr. Scientist, Molecular Biotechnology, Sigma-Aldrich Although there are many techniques to study epigenetic marks such as DNA- and histone-methylation, on a genomic scale, there exists a need in the fiel... 7 years ago | 33 mins Visualizing DNA Methylation (5mC) on a Specific Genomic Locus (SEPTIN9) 02 Dr. Vikas Palhan, Sr. Scientist, Molecular Biotechnology, Sigma-Aldrich Although there are many techniques to study epigenetic marks such as DNA- and histone-methylation, on a genomic scale, there exists a need in the fiel... 7 years ago | 37 mins Cartilage Engineering and Regeneration Marcy Zenobi-Wong, PhD Our laboratory engineers microenvironments to control the fate of cells being used in tissue repair, with the main application being cartilage lesions... 6 years ago | 34 mins Load more
