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    • Evaluations of a New Ionic Liquid Stationary Phase with PEG Like Selectivity
      Evaluations of a New Ionic Liquid Stationary Phase with PEG Like Selectivity Leonard M. Sidisky, Supelco R&D Manager Recorded: Oct 31 2012 3:00 pm UTC 49 mins
    • Geminal dicationic and polyionic ionic liquids have been prepared for use as stationary phases in capillary gas chromatography. These materials are known to provide higher thermal stability for gas chromatography, broader liquid working ranges and broader selectivity ranges than monocationic ionic liquids and polymeric based stationary phases with similar polarity. Recently, a new ionic liquid stationary phase has been developed that provides a selectivity very similar to a polyethylene glycol (PEG) selectivity but with increased thermal stability and lower bleed. We will compare and contrast the similar but unique selectivity of this new phase with traditional PEG phases using a wide variety of different sample types. We will demonstrate the improved thermal stability and lower bleed through a series of different studies and applications.

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    • Ionic liquid GC columns for the quantitation of trans fatty acids in fats & oils
      Ionic liquid GC columns for the quantitation of trans fatty acids in fats & oils Pierluigi Delmonte, Ph.D - U.S. Food and Drug Administration Recorded: May 16 2012 3:00 pm UTC 39 mins
    • The fatty acid composition of a fat or oil is most commonly assessed by gas chromatography, following conversion of the fatty acids methyl esters. The current most refined analytical methods for the quantitation of trans fatty acids rely on the separations provided by long cyanopropyl siloxane capillary columns. The introduction of capillary columns coated with ionic liquids, such as Supelco SLB-IL111, provide an alternative separation tool characterized by a higher stationary phase polarity and selectivity toward geometric and positional isomers of unsaturated fatty acids. The use of these novel capillary columns can provide more refined separations of complex lipid samples. As a result, most conjugated linoleic acid isomers (including t7,c9- and c9,t11-18:1 FA) can be quantitated in a single separation using a 100 m SLB-IL111 capillary column and most 18:1 FA positional and geometric isomers can be separated using a 200 m SLB-IL111. Ionic liquid columns provide more detailed FA profiles, especially for unsaturated fatty acid positional/geometric isomers.

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    • Liquid-Cooled IT for the Masses:  Achieving a Data Center PUE of 1.1
      Liquid-Cooled IT for the Masses: Achieving a Data Center PUE of 1.1 Tahir Cader, HP Servers Distinguished Technologist Recorded: Jan 22 2015 6:00 pm UTC 59 mins
    • Data center energy efficiency is being attacked from numerous directions, including power distribution innovations, the creation of hardware better suited to customer applications (to drive better IT utilization), co-designing data centers with IT solutions, and cooling system innovations.

      With respect to cooling systems, the widely-recognized Power Usage Effectiveness (PUE) from The Green Grid (TGG), which is a direct measure of data center energy efficiency, has been used to great effect to continuously drive down “traditional” air-cooled data center PUEs. In the high performance computing (HPC) space, where 40 kW+ rack power densities are commonplace, more aggressive cooling technologies such as liquid-cooling, are seeing rapid adoption. There is also increasing evidence that liquid-cooling is making its way into non-HPC data centers. The presentation will cover such topics as:

      · Data center energy efficiency trends
      · An overview of liquid-cooling technologies
      · The role that liquid-cooled IT is playing in driving improved energy efficiency – towards a PUE of 1.1
      · The challenges of implementing liquid-cooling in the IT and data centers

      The goal is to help demystify liquid-cooling. Finally, The Green Grid’s recently announced Liquid-Cooling Work Group will be described.

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    • Introduction to Liquid Chromatography
      Introduction to Liquid Chromatography Professor Peter Schoenmakers Recorded: Jan 19 2010 4:00 pm UTC 51 mins
    • In this webinar, Professor Peter Schoenmakers will provide insight into the various LC techniques, including:

      * An overall perspective of current usage and applications of the various techniques.
      * A description of how the techniques developed, starting from paper chromatography up-to current "high tech" two-dimensional separations.
      * A more detailed focus on the concept of various methods.

      Often portrayed more as magic than science, popular television series such as CSI have aroused great interest in analytical chemistry. Forensic science relies on separation science.

      Peter Schoenmakers' webinar will also, in a light-hearted manner, put LC methods into the correct perspective for forensic science.

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    • Designing an Energy Efficient Datacenter Using Warm Water Cooling Technology
      Designing an Energy Efficient Datacenter Using Warm Water Cooling Technology Roger Smith, Mississippi State University and John Lee, Cray Inc. Recorded: Apr 15 2014 6:00 pm UTC 59 mins
    • In this 1-hour webcast, Cray customer Mississippi State University will share best practices in maximizing datacenter energy efficiency and explain why they chose the Cray® CS300-LC™ cluster solution based on Intel® Xeon® processors and Xeon Phi™ coprocessors. Topics will include architecture and facility considerations such as site selection, risk factors and issues impacting TCO. Attendees will learn about key benefits of the CS300-LC’s innovative design—which uses warm water heat exchangers instead of chillers to efficiently cool the system and maximize performance—as well as remote monitoring and cooling system management.

      A Q&A session will be held following speaker presentations. Sign up today and join the conversation!

      Join the webcast to learn about:
      1. Key factors to consider when choosing a cluster architecture with liquid cooling
      2. Achieving significant power savings, reliability and performance scalability with managed cooling control.
      3. Optimizing power efficiency and system performance using Intel® Xeon® processors and Xeon Phi™ coprocessors

      About Cray
      Cray is a global supercomputing leader with a comprehensive portfolio of compute, storage and Big Data analytics solutions. Cray’s expertise enables fast application results and real-time discovery in technical and scientific computing.

      About Mississippi State University
      The High Performance Computing Collaboratory at Mississippi State University is a coalition dedicated to advancing computational science and engineering using high performance computing. Mississippi State consistently ranks among the nation's fastest academic computing sites on the TOP500 list.

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    • Developing Practical Single-Use Processes for New Vaccine Formulations
      Developing Practical Single-Use Processes for New Vaccine Formulations Kirsten Strahlendorf Recorded: May 16 2017 2:00 pm UTC 76 mins
    • New vaccine process designs – and all the kinks that go with them – are typically hammered out in a small scale capacity, for example, prior to manufacturing for early phase human clinical trials. They are then upsized and further defined for industrial scale to supply the vast market. Single-use technologies (SUTs) have been a hot topic for several years now and their advantages well-known: easy product changeover, processing in lower classification areas, reduced CAPEX, elimination of glass, sterility assurance, to name a few. In vaccine manufacturing, SUTs are used throughout the processing stages, from cell culture all the way to filling. SUTs are quickly and conveniently designed, purchased and implemented for short-term manufacturing of clinical trial phase materials. Here a large percentage of new vaccines in Research and Development do not even make it to market.

      As the final production stages are critical as they are the last stages before patient injection, the scope of thisarticle covers SU applications involving drug substance formulations, adjuvant processing, final bulk formulation and filling. The actual process itself may include some or all of the following: filtration, pumping, ingredient addition, mixing, adsorption, filling, labelling, sampling and and storage.

      In this presentation only liquid formulations (“presentations”) will be discussed.

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    • Basic Principles of Solid Phase Microextraction (SPME) Method Development
      Basic Principles of Solid Phase Microextraction (SPME) Method Development Emanuela Gionfriddo, Ph.D.; Research Associate under Prof. Janusz Pawliszyn, University of Waterloo (ON, Canada) Upcoming: May 31 2017 1:30 pm UTC 75 mins
    • For the past two decades, Solid Phase Microextraction (SPME) has represented a convenient alternative to conventional sample prep procedures. SPME allows the simultaneous extraction and enrichment of analytes of interest from a given matrix in a single step while avoiding, or drastically minimizing, the use of organic solvents and time-consuming cleanup procedures.
      Like any other analytical method, the various parameters governing the SPME process need to be carefully optimized in order to achieve robustness and sensitivity. However, certain aspects of SPME method development are often overlooked by many users, leading to unsatisfactory performance of the technique.
      This webinar will shed light into several aspects of SPME method development. The presentation will include a theoretical explanation of SPME fundamentals and practical suggestions to overcome common errors and bias encountered when using SPME.
      The webinar is divided in three main sections: 1) optimization of extraction conditions 2) matrix modifications 3) optimization of desorption conditions for gas and liquid chromatography. Each section is divided in various subsections dedicated to each parameter affecting the performance of the SPME technique. The webinar attendees will be guided through comprehensive understanding of the technology and the critical parameters that influence the extraction process with practical examples from already existing methods.

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    • Understanding Cell Culture Media Composition to Improve Outcomes
      Understanding Cell Culture Media Composition to Improve Outcomes Brian Posey Recorded: Jul 28 2016 4:00 pm UTC 59 mins
    • Cell culture media is required for successful and reproducible research but the catalog is full of acronyms and various formulation tables. Classical mammalian cell culture media formulations are very diverse both in terms of the number available and the concentration of constituents. Additionally, each medium was designed for specific cell types and culturing conditions.

      This webinar will cover:
      •The composition, characteristics, environmental factors, and additional supplements required to create optimal conditions for growth and productivity.
      •Determining the right formulation for your application.
      •Serum usage and helpful tips for optimizing your culture conditions.

      Speaker Bio:
      Brian Posey is a Product Development Manager for cell culture media at Corning Life Sciences. Brian has over 10 years experience in cell biology and industrial scale cGMP manufacturing of both liquid and powder cell culture media. Since joining Corning in 2012, Brian has led numerous innovative technology projects for the media business ranging from customer technology transfer for production scale-up to developing new serum-free media for industrial and stem cell lines.

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    • Planning for financings in volatile markets
      Planning for financings in volatile markets Anna Pinedo and James Tanenbaum, Morrison & Foerster; Brian Maier, Geoffrey Goodman and Gregory Ogborn, Wells Fargo Recorded: Jul 12 2016 3:00 pm UTC 102 mins
    • Volatile capital markets and the rapidly changing financial landscape make it important for issuers to recognise changes quickly and adjust their financing strategies accordingly.

      For example, for an issuer that contemplated an IPO or is in the IPO queue, it is important to become familiar with other financing alternatives, such as venture debt or late-stage or mezzanine debt, as well as institutional equity private placements. Each of these markets is quite different. Familiarity with investor expectations and documentation requirements is essential in order to put your company in the best position to make crisp decisions. For issuers that already have their securities listed on a non-US securities exchange, which may offer limited liquidity, it may be time to consider undertaking a US IPO in order to establish a more liquid market for their securities. Already public companies considering their next capital raise also must be nimble - a PIPE transaction may be an attractive (and available) financing alternative. During this session, the speakers will discuss:

      •Current market conditions;
      •Financing alternatives for pre-IPO companies;
      •The market for venture debt;
      •The late-stage (or cross-over) private placement market;
      •Options to consider on the way to an IPO;
      •The ReIPO™
      •Financing alternatives for recently public companies; and
      •PIPE transactions and other financing alternatives.

      The webinar's speakers will be:

      -Geoffrey Goodman, managing director, equity capital markets, Wells Fargo
      -Gregory Ogborn, director, equity capital markets, Wells Fargo
      -Brian Maier, vice chairman, Wells Fargo
      -Anna Pinedo, partner, Morrison & Foerster
      -James Tanenbaum, partner, Morrison & Foerster

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