HME lipidic Pellets for Paediatric Application. An Investigation of the Effect a

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Presented by

Dennis Douroumis, Professor in Pharmaceutical Technology and Process Engineering at University of Greenwich

About this talk

Hot Melt Extrusion (HME) is an established processing technology that can be used for the development of paediatric formulations. The processing of lipids via HME has been proved ideal for high drug loaded dosage forms with sustained release of drugs. The study investigates the effect of the lipid type and the food grade on the dissolution rates of extruded pellets or extemporaneous formulations. The stability of lipidic formulations is a very important aspect especially for paediatric applications. Here the stability of various formulations comprising of GRAS excipients is also examined.

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