In Depth Characterization with Mass Spectrometry and Orthogonal Methods of...

Logo
Presented by

Bruno Genet, Lab head Structural Analysis MS at Sanofi

About this talk

Full Title: In Depth Characterization with Mass Spectrometry and Orthogonal Methods of Conformers in a Trispecific HIV Antibody Presented by Bruno Genet, Lab head Structural Analysis MS at Sanofi The initial characterization of a trispecific anti-HIV antibody lead to an aberrant two-peaks size exclusion chromatography profile. In such case, a column interaction is suspected, but a possibility of actually having conformers was taken into consideration. We have used both analytical characterization, structural analysis and molecular dynamics to cross all the informations. The mass spectrometry toolbox has been largely used with native and denaturing MS, ion mobility and direct infusion to carefully study both the antibody and the antigens interactions.

Related topics:

More from this channel

Upcoming talks (26)
On-demand talks (302)
Subscribers (29725)
BioPharma Webinars aims to keep its global audience abreast of all developments in the areas of Drug Development, Manufacturing, Quality Assurance, Outsourcing and Regulatory Affairs, with only the highest quality webinars, presented by the most respected people, working with companies in Pharmaceutical, Biopharmaceutical, Biologics and Biotech Industry.