Advanced Technologies for Media and Process Optimization for Biologics Manu...
Dr. Yaron Silberberg at Ajinomoto Genexine and Dr. Mehran Rafigh at Yokogawa
About this talk
Full title: Advanced Technologies for Media and Process Optimization for Biologics Manufacturing
Cell culture media composition and upstream bioprocess conditions are crucial factors affecting protein yield in the production of biologics and biosimilars. Recently, advanced new techniques were developed that use IT approaches, including computer simulation of bioprocesses, AI tools and ‘multi-omics’ methods for analysis of cellular metabolic pathways. These techniques allow optimization of both process and media composition for maximizing culture performance and protein production. In my talk, I will discuss the importance of cell culture media optimization and feeding conditions for achieving the most out of biologics pipelines. I will also discuss about other supplements that can help achieve faster cell growth and higher productivity.
Main topics of my talk:
DoE approaches for media formulation and feeding optimization
‘Digital Twins’ bio-simulations for reducing wet data requirements and allowing rapid optimization of feeding manner
Multi-omics and metabolic flux analysis for identification of metabolic bottlenecks and critical media components, for development of enhanced basal and feed media
Supplements for productivity enhancement
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