USP : Methods for Moisture Determination and Karl Fisher Titration

Presented by

Bruce Herzig, Sr. Application Scientist, Merck KGaA, Darmstadt, Germany

About this talk

Many Pharmacopeia materials contain water as hydrates or in adsorbed form. Therefore the determination of the water content is important to maintaining compliance with the Pharmacopeia guidelines. Generally one of the three methods are given in the monographs, Method I (Titrimetric), Method II (Azeotropic), or Method III (Gravimetric). This poster will discuss the application of these methods to moisture determinations focusing on Karl Fischer techniques.

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