CRISPR Activator Libraries: Benefits of a whole genome gain-of-function screen

Presented by

Andrew Ravanelli, Ph.D. Senior R&D Scientist, Genome and Epigenome Editing

About this talk

CRISPR-Cas9 nucleases have revolutionized genome editing enabling unprecedented efficiency of targeted mutagenesis. The ability to perform large-scale, whole genome loss-of-function screens has allowed for the rapid identification of gene pathways and targets relevant to drug resistance and disease. The CRISPR SAM activator libraries extend the reach of whole genome screening beyond simple knockout, delivering transcriptional co-regulators to a specific human or mouse target sequence using modified dCas9/gRNA complexes. In this webinar, we will introduce new strategies for forward genetic screening using CRISPR SAM activator libraries. We will discuss the application of this technology as it pertains to experimental design, delivery mechanisms, data analysis, and target validation.

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