Sports Drug Testing: Chromatography & Mass Spec-Based Approaches

Presented by

Professor Mario Thevis

About this talk

Doping control analysis predominantly utilises chromatography and mass spectrometry-based approaches to detect prohibited substances and methods of doping. These compounds and methods present both low and high molecular weight analytes of xenobiotic or natural / endogenous origin, which are to be detected, and occasionally quantified, using state-of-the-art instruments. The majority of the employed tools provides low resolving power. However, high resolution / high accuracy mass spectrometry has gained much attention recently due to: constantly increasing analytical requirements concerning the number of target compounds; the complexity of analytes (e.g. peptides and proteins); and the desire to accelerate analyses and obtain information (allowing for retrospective data mining). A selection of compounds, new challenges, and methods currently employed in doping control laboratories will be presented to the audience including, for example: new anabolic agents referred to as selective androgen receptor modulators (SARMs); insulins; so-called "releasing peptides" that stimulate the endogenous production of natural hormones; and ways of manipulating drug tests.

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The Year of Education came about through discussions between 3 professors who actively teach chromatography: * Professor Harold McNair, Virginia Tech, Blacksburg, USA * Professor Pat Sandra, University of Ghent, Belgium * Professor Peter Schoenmakers, University of Amsterdam, Netherlands "The first activity is a free webinar on gas chromatography, followed by a number of other activities, more webinars, online short courses, tutorials, instruction videos and much more! 2010 will be a year full of activities. Many experts will be involved, from university and industry. We believe all chromatographers should actively take part in this: in teaching, telling their employees and students to take courses. This is a chance they should not miss!"