Early Chemical Development on BMS-986095 for Hepatitis C Virus
Changxia Yuan,Senior Research Investigator, Bristol Myers Squibb and Scott Newman, Customer Consultant, Elsevier
About this talk
Drug development is the process of bringing a new pharmaceutical drug to the market once a lead compound has been identified through the process of drug discovery. Chemical development of the synthetic/production process impact go/no go decisions of lead molecules. These include
•Developing or inventing new routes for important process intermediates at scale
•Optimizing reaction conditions for multiple routes based on novel reactants
•Yield considerations at each step
Each of these will be examined using a small molecule Hepatitis C nucleotide polymerase inhibitor that has been developed by BMS as a model.