DNA-encoded libraries in drug discovery

DNA-Encoded library (DEL) screening is now commonly used in the pharmaceutical industry to find novel chemical matter that modulates protein targets of interest. A DEL is a mixture of millions of drug-like small-molecules, where each molecule is conjugated to a DNA-oligomer that encodes its chemical structure. The composition of a DEL mixture can be readily interrogated before and after interaction with a protein target by Next Generation Sequencing, and small-molecules that selectively bind the target identified. We’re excited to invite you to a webinar on this topic that Dr. Alex Satz, senior director of DEL strategy and operations at WuXi AppTec, will talk about the current learnings in DEL design, synthesis, and screening, followed by a presentation from Dr. Andreas Brunschweiger of TU Dortmund University on research demonstrating the role of cheminformatics and DNA-encoded chemistry in compound identification. About speakers: Alex Satz has 15+ years experience building DNA encoded library (DEL) platforms, and is currently the senior director of DEL strategy and operations at WuXi AppTec. Prior to WuXi AppTec, Alex led the Roche DEL platform in Basel Switzerland, and helped to develop the first industrial-scale DEL platform at Praecis Pharmaceuticals and GlaxoSmithKline. Andreas Brunschweiger is a group leader at the Departmend of Chemistry and Chemical Biology of TU Dortmund University. His current research interests include the development of computer-assisted tools for DNA-endoced library design, synthesis and encoding strategies that expand the chemical space of DNA-encoded libraries, and asssays for hit identification.