The traditional data center has emerged into a distributed, hybrid infrastructure, located on-premises, in the cloud, and at the edge. Protecting it requires a different way of thinking, combining capabilities from multiple disciplines. We'll explore current visibility and segmentation capabilities that empower simplified prevention, detection, and remediation of different attack classes such as ransomware and supply chain attacks. We'll present the first hardware-based micro-segmentation solution powered by Supermicro, NVIDIA DPU and Akamai/Guardicore unique micro-segmentation capabilities.