How to Design a Successful 3D Tumor Model Co-Culture Study

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Presented by

Mara Gilardi, PhD, Immuno-oncology Subject Matter Expert, Champions Oncology

About this talk

The transition from traditional 2D cell cultures to 3D tumor models has revolutionized preclinical oncology research by providing more physiologically relevant environments for studying tumor biology and drug responses. The advent of immunotherapies and stroma-targeted therapies has dramatically increased the need for more complex in vitro models replicating the TME and cancer immune interactions. However, the complexity of 3D tumor models and the additional challenge of adding the complexity of recreating an in vitro immune and stroma microenvironment to test current combinatorial treatments also introduces significant difficulties. This comprehensive webinar will teach you the essential steps to design a robust 3D tumor model co-culture study. Our expert presenter will guide you through: 1. Model Selection and Target Expression Validation: Choosing the most relevant tumor models and validating target expression. 2. Donor Selection: Best practices for selecting donors to account for variability and ensure robust results. 3. Assessment of Tumor to Immune Cell Ratio: Techniques for accurately assessing and optimizing the tumor-to-immune cell ratio in your cultures. 4. Identifying the Right Controls: Strategies for selecting the appropriate controls to validate your study results. 5. Choosing the Best Readouts: Insights on selecting the most informative readouts to capture meaningful data. Ensure you secure your spot today and take the first step towards designing a successful 3D tumor model co-culture study.
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