Beyond Seizure Counts: Expanding Endpoints in Pediatric Epilepsy Trials

Many clinical trials in pediatric epilepsies quantify seizures as an endpoint. However, change, in some patients, is more subtle than can be measured by a seizure diary. This webinar will bring together seasoned experts in clinical trial operations and strategy, alongside patient advocacy and public health professionals, to delve into the evolving landscape of clinical trial endpoints for pediatric epilepsies. Traditional clinical trials for pediatric epilepsy often rely on seizure frequency as the primary endpoint. However, this approach does not always capture the full spectrum of patient experiences, especially when changes are subtler than what seizure diaries can document. This webinar is set to address this pivotal issue, focusing on the need for more comprehensive and patient-centered endpoints. Participants will gain valuable insights into the current trends in endpoint development, particularly for developmental and epileptic encephalopathies (DEE). These insights will not only reflect the latest scientific advancements but also incorporate the nuanced perspectives of those living with these conditions. The key learning points for the audience will include: Trends in endpoints for DEE Broadening the scope of clinical trial endpoints: Seizure diaries are commonly used as endpoints in pediatric epilepsy trials but these measures may not capture subtle and meaningful changes in some patients, and this webinar explores trends in developing more nuanced and patient-centric endpoints Transforming challenges into actionable research: The webinar will emphasize how families, advocacy groups and researchers can collaborate to identify measurable, impactful outcomes that reflect the lived experiences of children with rare epilepsies This webinar can push the boundaries of research to accommodate the diverse and real-world needs of young patients and their families.