Existing APT and Ransomware solutions only address specific parts of the kill chain, making them ineffective at completely stopping APT and Ransomware attacks. Powered by multiple levels of implementation of machine learnings on malware, DGA and other attack behaviors, We will explore holistic approaches that addresses every step of the kill chain making it the only fully integrated security solution with NGFW, EDR and MDR today that can accurately detect and mitigate APT/Ransomware attacks from network to endpoints.