Enabling CAR-T Screening in 3D Tumor Spheroids

Webinar Date & Time: Mar 30 2017 12:00 p.m. EST Chimeric antigen receptor (CAR)-T cells, which are engineered to recognize target cell surface antigens expressed on tumor cells, have shown promise to affect complete remission in patients with B-cell malignancies. However, applying this approach to target solid tumors has resulted in adverse effects in clinical studies. Methods for testing different models of CAR-T cells in vitro can provide further insight into viable antigen targets. Historically, two-dimensional (2D) cell culture models have been used in drug discovery. However, more elaborate, three-dimensional (3D) cell culture models better mimic the in vivo tumor microenvironment and help bridge the gap between in vitro studies and clinical outcomes. In this special joint webinar, panelists from ProMab Biotechnologies, DiscoverX, and Corning Life Sciences will present data on a high-throughput, easy-to-use, highly reproducible method for screening CAR-T cells in a 3D cell culture model by combining various technologies. Speakers: Van Dang, D.V.M., Ph.D. Scientist and coordinator for CAR-T research ProMab Biotechnologies, Inc. Abhi Saharia, Ph. D. Director, Cell-based Assays and Biologics DiscoverX Audrey Bergeron Applications Scientist Corning Life Sciences