Organogenesis to Oncogenesis

Organogenesis to Oncogenesis: Modeling Development and Cancer with Organoids Organoid cell culture allows mammalian stem cells to differentiate and self-organize into three-dimensional organ-like tissues that reflect the key structural and functional properties of the organs from which they are derived. In addition, organoids can be grown from patient-derived healthy and tumor tissue to provide genetically and phenotypically stable personalized preclinical models. Organoid technologies therefore provide a unique in vitro system in which to study human organ development and cancer. In this webinar, Dr. Regan will discuss the use of organoid technologies to study organogenesis and cell fate determination in the postnatal mammary gland. In addition, the use of patient-derived organoids (PDOs) to elucidate the molecular mechanisms that regulate oncogenesis and contribute to tumor heterogeneity in colon cancer will be discussed. Presenter: Dr. Joseph Regan graduated from The Institute of Cancer Research (University of London, UK) with a Ph.D. in Cell Biology and received postdoctoral training at the Breast Cancer Now Research Centre (London, UK) and the Max Planck Institute for Molecular Genetics (Berlin, Germany). Dr. Regan subsequently worked as a Research Scientist with Bayer AG and the Charité Medical University (Berlin, Germany), where he uses patient-derived organoid models to study cancer stem cells and tumor heterogeneity in colon cancer.