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Vaccine Production and R&D with Corning Solutions – A New Approach

Vaccines are considered to be one of the biggest public health achievements of the past century, and the concept of stimulating the organism’s immune response is the basis underlying vaccination. Vaccines act by initiating the innate immune response when activating antigen presenting cells, inducing a protective response towards a pathogen. These agents may contain live-attenuated, inactivated, or only parts of a pathogen. In this context, Corning provides a diverse set of single-use products for upstream vaccine manufacturing needs. As scale-up progresses, vessels and surfaces constantly increase in space efficacy, reducing the cost and minimizing the labor per titer. This presentation aims to provide background information about the main forms of vaccine designs, R&D and manufacturing workflows, and updated data generated in Corning’s application labs.

Presenter Bio: After graduating from Biochemistry in the University of Santiago (Chile), Constanza pursued directly a career in the Chilean Vaccine R&D industry, developing as a bioprocess scientist for both bacterial and viral vaccines in the field of animal health, being in charge of scale-up, and tech transfer with manufacturing plants. She furthered developed her career in Belgium as a bioprocess scientist, this time in the field of recombinant protein production, pursuing protocol optimization and scale-up experiments with suspension mammalian cell lines. Constanza is currently a field applications scientist in Corning for the EMEA region, providing customers with in-depth technical support, presenting seminars and trainings, and assisting customers in experimental set-up and troubleshooting.
Recorded Apr 24 2020 42 mins
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Constanza Curotto
Presentation preview: Vaccine Production and R&D with Corning Solutions – A New Approach

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    - Bacteriological analysis techniques and standard methods for bacterial enumeration
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    - Tips for proper water sample collection, handling, and identification
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    Speaker Bio:
    Mourad Ferhat, Ph.D.,
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  • Maximizing Cell Yields Using Perfusion Oct 1 2020 4:00 pm UTC 60 mins
    Dr. Ann Rossi Bilodeau
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    About the Presenter:
    Dr. Ann Rossi Bilodeau graduated from the University of Rochester School of Medicine and Dentistry with a Ph.D. in Pharmacology and received postdoctoral training at the University of Chicago. Ann began her career with Corning Life Sciences as the Applications Lab Manager where she utilized her strong academic and industry research experience to direct the activities of the Applications Laboratory. Currently, Dr. Rossi Bilodeau is the Senior Bioprocess Applications Scientist, functioning as the technical lead for generating applications in support of Corning Life Sciences’ Bioprocess and Cell/Gene Therapy portfolios including CellCube and HYPERStack platforms.
  • Epithelial Barrier Homeostasis and Response to Infections Recorded: Sep 29 2020 59 mins
    Dr. Francesco Boccellato
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    About the presenter:
    Dr. Francesco Boccellato studied at Sapienza University of Rome. Ever since he was a student, he's been interested in the impact of pathogens in causing cancer in humans. During his Ph.D. in Rome, he studied the role of the Epstein - Barr virus (EBV) in deregulating microRNAs in diffuse large B cell lymphomas. After his Ph.D., Francesco moved to Berlin to the Max Planck Institute for Infection Biology, were he became interested in the causality of bacterial infection in human cancers. To study the impact of infection on healthy epithelial barriers Francesco invented a new cultivation systems for healthy epithelial cells called the mucosoids. The mucosoids are monolayers of polarised epithelial cells that recapitulate all the functions of an epithelial barrier in the body, including mucus production. Francesco recently started his independent group in the University of Oxford (UK) at the Ludwig Institute for Cancer Research.
  • 3D Cell Cultures and Tissue Clearing Recorded: Sep 24 2020 52 mins
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    - Tissue Clearing and Labeling Techniques for 3D-CCM: 8:20 - 17:20
    - High Content Imaging Considerations: 17:21 - 28:07
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    Webinar highlights:
    - Introduction: 00:00 - 2:23
    - HUB Organoids - Adult Stem Cell-Derived Organoids: 2:24 - 7:55
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    - Q&A Session: 30:19 - 44:11
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    Segurança e Qualidade em Laboratórios - Impacto da vidraria
    Jerónimo Figueiredo - Business Operations Manager
  • Organogenesis to Oncogenesis Recorded: Sep 15 2020 46 mins
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    Presenter:
    Dr. Joseph Regan graduated from The Institute of Cancer Research (University of London, UK) with a Ph.D. in Cell Biology and received postdoctoral training at the Breast Cancer Now Research Centre (London, UK) and the Max Planck Institute for Molecular Genetics (Berlin, Germany). Dr. Regan subsequently worked as a Research Scientist with Bayer AG and the Charité Medical University (Berlin, Germany), where he uses patient-derived organoid models to study cancer stem cells and tumor heterogeneity in colon cancer.
  • 最新バイオロジクス技術を用いた細胞・遺伝子治療開発の海外導入事例を紹介 Recorded: Sep 8 2020 60 mins
    コーニングインターナショナル株式会社  ライサイエンス事業部 石渡 孝至
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  • Generando un Microambiente Óptimo en Todas las Etapas del Cultivo Celular Recorded: Aug 28 2020 26 mins
    Constanza Curotto
    Corning y Aplicaciones en Bioprocesos: Medio de Cultivo y Suero - Parte 3/3

    El medio de cultivo y suero son componentes esenciales del cultivo celular – suministrando nutrientes y factores claves para las células – en ese sentido, seleccionar los productos óptimos es esencial.
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    El portfolio de Corning incluye:
    -Diversas formulaciones de medio estándar para requerimientos específicos
    -Medio libre de suero y medios especializados
    -Suero estándar y premium
    -Selección de suero especializado.

    Biografía del Expositor
    Luego de graduarse como Bioquímico de la Universidad de Santiago de Chile, Constanza prosiguió su carrera en la industria farmacéutica veterinaria, desempeñándose como Científico de Bioprocesos tanto para el desarrollo de vacunas bacterianas y virales, estando a cargo de los procesos de escalado y generación de antígenos. Luego continuo su carrera en Bélgica, esta vez en el área de la producción de anticuerpos y proteínas recombinantes en sistemas celulares en suspensión, generando optimización de protocolos y experimentos de escalado.
  • Multiplica Tus Células, No Tu Trabajo: Cómo Escalar Cultivos en Suspensión Recorded: Aug 27 2020 28 mins
    Constanza Curotto
    Corning y Aplicaciones en Bioprocesos: Células en Suspensión - Parte 2/3

    Los procesos en suspensión juegan un rol clave en el mercado de biofarmacéuticos, donde sistemas celulares en suspensión son usados para producir anticuerpos y proteínas recombinantes. En este contexto, la selección de las plataformas de cultivo adecuadas favorece el uso eficiente del espacio, reduce costos y horas de trabajo. En este Webinar haremos una revisión general del portfolio de Corning para el cultivo en suspensión, aplicado tanto al ámbito de la investigación y desarrollo y producción. Apoyado además con datos experimentales generados por nuestros equipos de desarrollo.

    Biografía del Expositor
    Luego de graduarse como Bioquímico de la Universidad de Santiago de Chile, Constanza prosiguió su carrera en la industria farmacéutica veterinaria, desempeñándose como Científico de Bioprocesos tanto para el desarrollo de vacunas bacterianas y virales, estando a cargo de los procesos de escalado y generación de antígenos. Luego continuo su carrera en Bélgica, esta vez en el área de la producción de anticuerpos y proteínas recombinantes en sistemas celulares en suspensión, generando optimización de protocolos y experimentos de escalado.
  • Corning HYPER Technologies: Compact Solutions for Cell Scale-Up [ENG. VERSION] Recorded: Aug 27 2020 35 mins
    Dr. Lindsey Parker
    Efficient cell scale-up is essential in biologics and vaccine production to facilitate optimal product yields, whilst reducing footprint and manhours, Corning introduces the HYPER vessel technology. Corning HYPERFlasks and HYPERStacks are multilayer vessels incorporating proprietary gas-permeable film technology, resulting in high surface area to volume ratio. Using HYPER vessels, scientists can generate greater yields than traditional cell culture technologies, saving time, space and labor.

    In this webinar we will provide a general introduction of the HYPER technology, as well as technical applications in the fields of cell and gene therapy and viral particle production.

    About presenters:

    Dr. Lindsey Parker
    Lindsey completed her Ph.D. in Tissue Engineering and Regenerative Medicine at the University of Leeds (UK), validating a bioreactor for the application of mechanical stimuli to MSC. She subsequently joined UCL as an industrial KTP associate, leading clinical research in umbilical cord- derived MSC scale-up in collaboration with a tissue bank. Lindsey is currently a Bioprocess Sales Specialist at Corning, providing specialist support in bioprocess ranges, such as advising on product selection, custom products, and providing training.
  • Corning HYPER Technologies: Compact Solutions for Cell Scale-Up [SP. VERSION] Recorded: Aug 27 2020 28 mins
    Constanza Curotto
    Efficient cell scale-up is essential in biologics and vaccine production to facilitate optimal product yields, whilst reducing footprint and manhours, Corning introduces the HYPER vessel technology. Corning HYPERFlasks and HYPERStacks are multilayer vessels incorporating proprietary gas-permeable film technology, resulting in high surface area to volume ratio. Using HYPER vessels, scientists can generate greater yields than traditional cell culture technologies, saving time, space and labor.

    In this webinar we will provide a general introduction of the HYPER technology, as well as technical applications in the fields of cell and gene therapy and viral particle production.
    About presenter:

    Constanza Curotto
    After graduating from Biochemistry in the University of Santiago (Chile), Constanza pursued directly a career in the Chilean Vaccine R&D industry, developing as a bioprocess scientist for both bacterial and viral vaccines in the field of animal health, being in charge of scale-up, and tech transfer with manufacturing plants. She furthered developed her career in Belgium as a bioprocess scientist, this time in the field of recombinant protein production, pursuing protocol optimization and scale-up experiments with suspension mammalian cell lines. Constanza is currently a field applications scientist in Corning for the EMEA region, providing customers with in-depth technical support, presenting seminars and trainings, and assisting customers in experimental set-up and troubleshooting.
  • Corning HYPER Technologies: Compact Solutions for Cell Scale-Up [FR. VERSION] Recorded: Aug 27 2020 48 mins
    Dr. Sonia Meconi
    Efficient cell scale-up is essential in biologics and vaccine production to facilitate optimal product yields, whilst reducing footprint and manhours, Corning introduces the HYPER vessel technology. Corning HYPERFlasks and HYPERStacks are multilayer vessels incorporating proprietary gas-permeable film technology, resulting in high surface area to volume ratio. Using HYPER vessels, scientists can generate greater yields than traditional cell culture technologies, saving time, space and labor.

    In this webinar we will provide a general introduction of the HYPER technology, as well as technical applications in the fields of cell and gene therapy and viral particle production.

    About presenters:

    Dr. Sonia Meconi
    Sonia’s scientific background covers different fields such as biochemistry, cell biology, and immunology where she obtained a Ph.D., specifically in human infectious diseases working on a daily basis in a biologic level 3 lab. After a post-doctoral fellow and lecturer experience, she took over the head of the R&D and production teams in a small biotech which developed human serological diagnosis assays for infectious and autoimmune diseases. She oversaw pathogens (bacteria and virus) expansion supervision for protein microarray tests. Then, she joined an international company as an Application Specialist for cell culture and purification, creating new cell culture media dedicated to vaccines and cell therapy markets. Now, she joined Corning as Bioprocess Specialist working for different suppliers for the biopharmaceutical industry.
  • Corning HYPER Technologies: Compact Solutions for Cell Scale-Up [GER. VERSION] Recorded: Aug 27 2020 35 mins
    Dr. Franziska Wienholz
    Efficient cell scale-up is essential in biologics and vaccine production to facilitate optimal product yields, whilst reducing footprint and manhours, Corning introduces the HYPER vessel technology. Corning HYPERFlasks and HYPERStacks are multilayer vessels incorporating proprietary gas-permeable film technology, resulting in high surface area to volume ratio. Using HYPER vessels, scientists can generate greater yields than traditional cell culture technologies, saving time, space and labor.

    In this webinar we will provide a general introduction of the HYPER technology, as well as technical applications in the fields of cell and gene therapy and viral particle production.

    About Presenter:

    Dr. Franziska Wienholz
    Franziska completed her Ph.D. in Molecular Genetics at the Erasmus MC,The Netherlands, focusing on studying DNA repair and related diseases. During her research, she acquired extensive knowledge on cell culture and patient-derived materials, molecular techniques, and genome editing.
  • Multiplica Tus Células, No Tu Trabajo: Cómo Escalar Cultivos Adherentes Recorded: Aug 26 2020 30 mins
    Constanza Curotto
    Corning y Aplicaciones en Bioprocesos: Células Adherentes - Parte1/3

    Un escalado eficiente es esencial en la producción de fármacos biológicos; el tipo celular, aplicación y espacio dictan cual es la plataforma más adecuada para cada proceso. En este Webinar haremos una revisión general de las plataformas de cultivo de Corning para células adherentes, y como estos pueden ser empleados para el escalado en aplicaciones de bioproduccion tales como producción de vacunas, terapias celulares y producción de vectores virales.

    Biografía del Expositor:
    Luego de graduarse como Bioquímico de la Universidad de Santiago de Chile, Constanza prosiguió su carrera en la industria farmacéutica veterinaria, desempeñándose como Científico de Bioprocesos tanto para el desarrollo de vacunas bacterianas y virales, estando a cargo de los procesos de escalado y generación de antígenos. Luego continuo su carrera en Bélgica, esta vez en el área de la producción de anticuerpos y proteínas recombinantes en sistemas celulares en suspensión, generando optimización de protocolos y experimentos de escalado.
  • Harnessing the Power of 3D Spheroids in Cancer Research Recorded: Aug 25 2020 60 mins
    Roxana Ghadessy, Ph.D. and Fiona Chang, Ph.D.
    In this joint webinar, Corning and Promega will present tools and solutions to support the continuous evolution of the spheroid model in 3D cell culture applications. Learn about how culture platforms optimized for single spheroid analysis or mass spheroid production can be coupled with novel real-time cell health assays and total RNA purification techniques. Furthermore, learn how to expand the spheroid workflow with downstream analysis of miRNA effects in cancer cell growth and metastasis.

    1. Turning the volume up on spheroid production with Corning Elplasia™ microplates - Roxana Ghadessy, Ph.D.

    Roxana is a Technical Marketing Manager for Corning Life Sciences, based in Singapore. In this role she is responsible for product awareness and education activities to highlight Corning’s workflow solutions in Cell Culture, Drug Discovery and other differentiated applications. Roxana has held previous roles in Sales and Product Management at Corning, BD Biosciences and Tocris. She received her Ph.D. degree in Pharmacology from the University of Bristol.

    2. A Complete Workflow for MicroRNA Analysis Paired with Novel Cell Health Assays for 3D Cultures - Fiona Chang, Ph.D.

    Fiona is an Applications Scientist at Promega Corporation, based in Singapore. She facilitates adoption of products by performing demonstrations, troubleshooting experiments, and giving trainings. Prior to joining Promega, Fiona received her Ph.D. in Biochemistry and Molecular Biology from Monash University, Melbourne. She has been working as a research fellow at the National University of Singapore before joining the Scientific Applications Group in 2018. Fiona has since been involved in applications in the Genomics, Genetic Identity, Applied Markets, Clinical Diagnostics and Cellular Analysis product areas.
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  • Live at: Apr 24 2020 2:00 pm
  • Presented by: Constanza Curotto
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