Engineering Integrated Multi-Tissue Platforms for Modeling Human Pathologies

Presented by

Kacey Ronaldson Bouchard, Ph.D., Associate Research Scientist, Columbia University

About this talk

Title: Engineering Integrated Multi-Tissue Platforms for Modeling Systemic Human Pathologies 3D CELL CULTURE SUMMIT MASTER SERIES Bioengineered tissue platforms offer a new paradigm for modeling human pathophysiology and testing drug efficacy and safety. To model whole-body physiology and systemic diseases, we developed the biomimetic InterOrgan platform in which matured human tissues are connected in a way that allows maintaining distinct functionalities of different organs. Each tissue is cultured in its own optimized environment and integrated via recirculating vascular flow containing monocytes, by a matured and selectively permeable endothelial barrier. Tissues linked by vascular perfusion maintained their molecular, structural, and functional phenotypes over four weeks of culture, recapitulate multi-organ toxicity of doxorubicin and clinically relevant miRNA biomarkers, and show utility for immune-oncology applications.
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