Cell invasion through extracellular matrix: advantages, tips and uses

Presented by

Hynda K. Kleinman, Ph.D.

About this talk

Tumor cells must detach from the primary tumor and invade through extracellular matrix to metastasize. In particular, the cells must attach, degrade, and migrate through the basement membrane matrix underlying blood vessels. A simple, rapid, reliable, flexible, and quantitative in vitro Invasion Assay was developed more than 25 years ago and is widely used today. This webinar will cover how the assay is performed, provide some tips for optimal and reproducible results, and discuss various uses of the assay with examples. The emphasis will be on using basement membrane extract (BME) and tumor cells but other matrices and endothelial cells will be mentioned.

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The Corning Scientific Seminar Series is a series of free, online technical presentations that provide novel tips, best practices and proven techniques to help advance your research. Delivered by scientists to scientists, these one-hour broadcasts offer useful information and tips for lab technicians and researchers.