A revolution is underway in manufacturing. Commonly known as Industry 4.0, the forces of AI and IoT are converging to transform how manufacturers optimize business operations, drive growth, and improve resiliency. In this presentation we will explore the drivers of change and the impact on the future of manufacturing and the importance of Small and Medium Manufacturers in this digital transformation. This includes detailing how Industry 4.0 is driving culture change behind new interactions between operational technology and information technology groups — integrations that will lead to profound opportunities. Along the way we will define key principles that will help us lead in this time of accelerating change.