Managing the patient pathway with MOSAIQ workflow tools
Hazel Rodgers discusses how her team has used IQ scripts to standardise critical workflow processes in the radiation oncology department, and how this delivers clinical benefits. Hazel is Deputy Head of Radiotherapy at St James's Institute of Oncology, Leeds (UK).
RecordedMay 7 201379 mins
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Generally speaking, physicists still find that computing with paper and pencil is in most cases simpler than computing with a Computer Algebra System (CAS). Although that is true in some cases, the working paradigm is changing: developments in CAS, and particularly recent ones in the Maple system, have resulted in the implementation of most of the mathematical objects and mathematics used in theoretical physics computations, and have dramatically approximated the notation used in the computer to the one used with paper and pencil, diminishing the learning gap and computer-syntax distraction to a strict minimum. In this talk, the Physics project at Maplesoft will be presented and the resulting Physics package will be illustrated through simple problems in classical field theory, quantum mechanics and general relativity, and through tackling the computations of some recent Physical Review papers in those areas.
Louise Wright, Principal Research Scientist, Data Science Group, NPL and Andrew Young, Applications Engineer, COMSOL
This webinar is sponsored by: COMSOL and The National Physical Laboratory (NPL)
If you are interested in correctly handling material properties in heat transfer modelling, then tune into this webinar with Louise Wright from the Data Science Group at the National Physical Laboratory (NPL).
Heat transfer modelling is used in a wide range of industries and research areas, including materials processing, food manufacturing, power generation, and aerospace. Reliable model results require reliable material properties, but it can be difficult to know how to get suitable values, particularly if the model involves very high or very low temperatures.
In this webinar, we will discuss NPL’s measurement capabilities for thermal behaviour and how they are extending these capabilities. You will also learn about NPL’s use of heat transfer modelling to design their kit and experiments.
The webinar will include a live demonstration and conclude with a Q&A session.
Dr. Ute Schmidt – Applications Manager at WITec GmbH
RISE – Raman Imaging and Scanning Electron – microscopy is a correlative approach that combines molecular and ultrastructural analysis. With this hybrid technique, information on the chemical composition of a sample provided by the optical Raman microscope is overlaid onto structural features imaged with a high resolution scanning electron microscope. Both methods can be controlled with software and the correlation carried out while the sample remains under vacuum. The integration of both techniques within a single instrument eliminates the necessity of manually locating the same measurement position, a notoriously time-consuming process with separate instruments.
In this webinar, the principles of state-of-the-art confocal Raman imaging as a tool for the analysis of molecular characteristics of a sample will be presented, then the manner in which this information can be linked to structural information acquired with scanning electron microscopy will be demonstrated. The advantages of seamless correlative investigation will be described and shown with several examples.
James P Nunn, MS, CHP, DABR Senior Medical Physicist Radiation Safety Officer LewisGale Hospital Pulaski
Approved for one credit for CAMPEP, MDCB, ASRT
As radiation-oncology clinics transition from paper to paperless environments, more documentation is being stored in computer databases. Medical-physics documentation was traditionally stored in large binders on a bookshelf and disparate Excel files on a PC hard drive. Historically this was the only option for storing the large volume of data required for regulatory compliance. In the last 5 years many vendors of radiation-oncology quality-assurance (QA) equipment have stepped up to fill this gap. Additionally, QA software is now available that combines the interfacing of hardware with QA systems. In this lecture I will cover some of the software packages available from vendors and will share the LewisGale experience in implementing one software package for integrated QA. I will conclude the lecture with some of my personal thoughts regarding suggestions for QA software vendors for the future.
Jochem Wolthaus, PhD, Utrecht University, University Medical Center Utrecht
AQUA is a departmental quality management software that centralizes all of the machine QA activities, helping to manage the complexity of quality assurance requirements in a radiation therapy department. As part of an MR Linac research project, Aqua was chosen to standardize and manage QA activities. It uses a centralized database to consolidate all QA tests, procedures and results in one location and offers a workflow manager to guide the users in their day-to-day QA tasks.
In this presentation, we will review how University Medical Center Utrecht utilizes Aqua to manage and monitor QA across the radiation therapy department.
With the Ray Optics Module, an add-on product to the COMSOL Multiphysics® software, you can use simulation to predict the paths of light rays, including diffuse and specular reflection, refraction, absorption and dispersion of polychromatic light. You can also analyse ray intensity, polarization and monochromatic aberrations.
This webinar will focus on how ray tracing can be combined with other types of physics in a model. For example, you can model the effects of thermal stress in high-powered laser focusing systems and even couple wavelength-scale modelling of antennas and semiconductor devices to ray tracing simulations on a much larger scale.
The webinar includes a live demonstration and will conclude with a Q&A session.
Daniel Letourneau, Associate Head of Medical Physics, Princess Margaret Cancer Centre
The quality control (QC) of radiation-therapy (RT) treatment units is essential to deliver safe and effective radiation-therapy treatments. The complexity of the equipment and treatment techniques demands that many different tests be performed with varying frequencies, making the management of an RT department’s QC programme a complex and time-consuming task. Many professionals such as therapists, service engineers and physicists are working in collaboration to meet the machine QC requirements.
AQUA is a departmental quality-management software that centralizes all of the machine QC activities, helping to manage the complexity of quality-assurance requirements in a radiation-therapy department. AQUA is a server-based application that can be accessed throughout a RT department using a web browser. It uses a centralized database to consolidate all QC tests, procedures and results in one location and offers a workflow manager to guide the users in their day-to-day QC tasks. QC tests in AQUA can easily be created or customized using a XML-based scripting language. Integration between AQUA and the Elekta linear accelerators and other measurement devices (such as MV flat panels, electrometers and 2D arrays) using a built-in software interface has been implemented to automate time-consuming tasks. Finally, review tools such as near-real-time dashboard, plotting tool and reports are available in AQUA to streamline machine-performance assessment.
In this presentation, we will review some of the main AQUA features such as the workflow manager, QC test scripting language, and the dashboard for performance and compliance review. We will also describe test automation for some QC tasks and review the impact on QC workflows and test frequency. We will then discuss the impact of efficient review tools on the ability to detect change in machine performance and to guide servicing decisions. Finally, we will review new features in the up-coming version of the software.
Carri Glide-Hurst, PhD DABR Henry Ford Health System, Anthony Doemer, Henry Ford Health System
The advent of MRI-guided radiation therapy has introduced MRI’s powerful soft- tissue contrast into the treatment room, offering strong potential for improved targeting in many disease sites. In February 2017, ViewRay’s MRIdian linear accelerator (linac) received FDA clearance and the first patient treatment using MRIdian® Linac was conducted at Henry Ford Cancer Institute in July 2017. In this webinar, two key physicists involved in this project, Anthony Doemer, M.S., and Carri Glide-Hurst, Ph.D., will present their commissioning and clinical experience. Initial site planning, shielding, and MR safety considerations will be shared. The design aspects and functionality of the double-focused MLC, mechanical, and radiation characterization and validation will be presented. Commissioning of the MRI system, including novel aspects such as distortion assessment and field homogeneity in the presence of the linear accelerator will be highlighted. First clinical images and treatment plans will be shared to highlight the first months of clinical operation.
Dr Hidde Ploegh, Senior Investigator, Boston Children’s Hospital
The ability to visualize immune responses non-invasively would have tremendous value for basic immunology. In pre-clinical models it would be possible to track events such as the host response to infections, to look at inflammation more generally, and to follow the course of interventions such as checkpoint blocking antibodies in the treatment of tumours.
PET imaging agents require a workflow compatible with the half-life of commonly used isotopes, and must take into account the pharmacokinetic properties of these agents. The specificity of what is being imaged requires the design of compounds that can distinguish between differences in metabolic activity (18F-fluorodeoxyglucose) or that serve as ligands for specific receptors, such as antibodies that recognize surface structures. We have used nanobodies, the smallest antibody-derived fragments that retain antigen-binding capacity. These fragments are ~15 kDa in size, are rapidly cleared from the circulation and are easily modified by chemo-enzymatic means for the installation of metal chelators or click handles to enable radiolabelling. Using nanobodies, we have been able to image various populations of immune cells, and based on longitudinal immuno-PET observations we have been able to make predictions of success and failure in immunotherapy of the B16 mouse melanoma model. The use of 89Zr-labelled nanobodies for immuno-PET will be a powerful adjunct to more conventional, invasive models, and will provide resolution superior to fluorescence- and luminescence-based models.
If you are interested in learning about photonics simulation using the COMSOL Multiphysics® software, then tune into this webinar.
Photonics (the generation, detection, and manipulation of light) plays a fundamental role in modern technology. It is used in a wide range of applications, such as telecommunications, medicine, computing, and manufacturing.
During this webinar, we will discuss using COMSOL Multiphysics® for photonics simulations, in particular periodic structures and crystals. We will show how modeling can provide insight into the design and characterisation of photonic devices. This includes solving for the propagation of electromagnetic waves, even in the presence of wavelength-dependent material properties, as well as multiphysics effects like heating or mechanical loading.
The webinar includes a live demonstration and a Q&A session during which you can ask questions.
Dr Albrecht Bartels, managing director of Laser Quantum
After the first demonstration of an optical frequency comb based on a mode-locked laser in 1999, Ti:sapphire lasers with repetition rates around 1 GHz were the sources of choice for scientists around the world. Their key feature was a mode spacing 10 times higher than that of comparable 100 MHz sources (simplifying mode identification) and the ability to generate a fully coherent super-continuum with 100 times more power per mode either directly from the cavity or using an external microstructured fibre (enhancing signal-to-noise ratio). The world’s first optical atomic clock was built in 2001 using a 1 GHz Ti:sapphire laser and subsequently it has been shown that these lasers indeed support an accuracy at the 10–20 level with a 1 s stability at the 10–17 level and optical linewidths at the millihertz level, i.e. ideal candidate clockworks for a new generation of optical atomic clocks. The Ti:sapphire technology has even been taken out to as far as 10 GHz, a regime where individual modes with powers in excess of 1 mW can be separated with a grating spectrometer and used individually for direct spectroscopy, spectrograph calibration or optical arbitrary waveform generation.
To overcome some of the disadvantages of early Ti:sapphire lasers (requirement for frequent alignment, cleaning and use of AO modulators for control purposes) and to make the full advantages of GHz frequency comb technology accessible to the science community, Laser Quantum has developed the hermetically sealed and permanently aligned taccor 1 GHz Ti:sapphire laser featuring an integrated pump laser with direct pump power control. This intervention free laser forms the basis for the new taccor comb system featuring an f-2f interferometer and full comb-stabilization electronics.
This webinar reviews the benefits of gigahertz Ti:sapphire frequency combs and focuses on the recent progress using Laser Quantum‘s hermetically sealed line of taccor lasers.
Professor Kai Bongs, Professor Miles Padgett, Professor Ian Walmsley, Professor Tim Spiller
The UK Quantum Technology Hubs led by the Universities of Birmingham, Glasgow, Oxford and York are offering fully funded PhD studentships in the areas of sensing and metrology, enhanced imaging, quantum computing and secure communications, Find out more about each hub’s research and their partners, and the studentship opportunities available.
The UK Quantum Technology Hubs are part of the UK government’s £270 million National Quantum Technologies Programme set up to exploit the potential of quantum science and develop a range of emerging technologies with the potential to benefit the UK.
If you are interested in modelling smart materials and MEMS using COMSOL Multiphysics®, then tune into this webinar.
Smart materials are materials whose properties or shape respond dynamically to stimuli in their environment. For example, piezoelectric materials experience strain under an applied electric field, while magnetostrictive materials deform in the presence of a magnetic field.
In this live webinar, you will learn how to model MEMS sensors and actuators based on smart materials for a wide range of applications, including vibration and active shape control as well as structural health monitoring and energy harvesting. We will also demonstrate the applicability of the COMSOL Multiphysics® simulation environment for coupling mechanical, electrical and thermal models of smart materials.
At the end of this webinar, you can ask questions during the Q&A session.
Robert Jeraj, Professor, Medical Physics, University of Wisconsin
In the fifth and final of our series of webinars showcasing presentations from the PMB 60th Anniversary Symposium, Robert Jeraj from the University of Wisconsin takes a look at what may lie ahead for medical physics in the next 60 years.
The physics of electromagnetic coupling through space is fundamental to modern technology. It is exploited in some devices such as RFID tags and directional couplers to communicate information. In other devices, electromagnetic interference (EMI) is an unwanted effect that must be controlled: for example, the problem of crosstalk in electrical circuits and cables. In this webinar we will discuss the simulation of electromagnetic coupling in a variety of different applications, considering examples of capacitive, inductive and radiative couplings in frequencies from the kHz to GHz range. We will show how modelling can provide insight into design, either to improve the quality of a communication device, or to mitigate EMI through effective electromagnetic shielding. A live demo will illustrate how to simulate antenna crosstalk using COMSOL Multiphysics®. We will conclude this webinar with a Q&A session.
Katia Parodi, Chair of Experimental Physics – Medical Physics, Ludwig-Maximilians-Universität München Germany
In the fourth of our series of webinars showcasing presentations from the PMB 60th Anniversary Symposium, Katia Parodi examines the key ingredients of modern adaptive radiotherapy, including fast computational models and methods for in-vivo dose/range assessment. She also takes a look forward to the era of biological guidance.
Carri K Glide-Hurst, PhD, DABR Senior Staff Physicist, Henry Ford Health System
Almost all clinics, small and large, use magnetic resonance images (MRI) in their treatment-planning workflows. Modern treatment planning requires images of high geometric fidelity with high spatial and contrast resolution to delineate disease extent and proximity to adjacent organs at risk. However, imaging protocols needed for accurate treatment planning differ significantly from those used in diagnostic radiology. As the integration of MRI into radiation oncology is expanding rapidly, a need exists to highlight the considerations for safe and effective implementation. This webinar will describe the major differences from diagnostic MRI, provide an overview of MRI safety and training models, introduce clinical-workflow considerations, and describe the development of a robust quality-assurance programme. Special considerations for motion management and treatment planning will be described.